17:0-16:1 PC-[d5]

17:0-16:1 PC-[d5] is a deuterated phospholipid commonly used in lipidomics and other biochemical research. Here are some key applications of 17:0-16:1 PC-[d5]:

Lipidomics Research: In lipidomics studies, 17:0-16:1 PC-[d5] is used as an internal standard for precise quantification of lipid species in biological samples. Its deuterated nature allows for easy differentiation from naturally occurring lipids in mass spectrometry analyses. This aids in accurate profiling of lipid compositions in various tissues, fluids, and cells.

Membrane Structure and Function Studies: The unique properties of 17:0-16:1 PC-[d5] make it valuable for studying membrane dynamics and lipid-protein interactions. Researchers can incorporate it into artificial lipid bilayers to observe its impact on membrane properties, such as fluidity and phase behavior. This can provide insights into the biological functions of lipid membranes and their role in cellular processes.

Pharmacokinetics and Drug Delivery: 17:0-16:1 PC-[d5] can be utilized to investigate the pharmacokinetics of lipid-based drug delivery systems. By tracking the behavior of this deuterated phospholipid in the body, researchers can understand the distribution, metabolism, and clearance of lipid nanoparticles or liposomal formulations. This information is crucial for optimizing drug delivery strategies and improving therapeutic efficacy.

Stable Isotope Labeling Studies: The deuterium labels in 17:0-16:1 PC-[d5] make it an excellent tool for stable isotope labeling experiments. It can be incorporated into metabolic studies to trace lipid biosynthesis and turnover in living organisms. This application is essential for elucidating metabolic pathways and understanding lipid metabolism in health and disease contexts.