12:0 Diether PC

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Category	Loadable Liposomes
Catalog NO.	BPG-3109
Product Name	12:0 Diether PC
CAS	72593-72-7
Molecular Formula	C32H68NO6P
Molecular Weight	593.86

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Product Information

Description	12:0 Diether PC is a glycerophospholipid having choline as the alcohol moiety, attached to the phosphate group. 12:0 Diether PC has two dodecane chains attached to the sn-1 and sn-2 positions of the glycerol backbone by ether bonds. It is useful in bicelles formation.
Synonyms	1,2-di-O-dodecyl-sn-glycero-3-phosphocholine; PC(12:0e/12:0e); 12-O-PC; DIODPC
IUPAC Name	[(2R)-2,3-didodecoxypropyl] 2-(trimethylazaniumyl)ethyl phosphate
Canonical SMILES	CCCCCCCCCCCCOCC(COP(=O)([O-])OCC[N+](C)(C)C)OCCCCCCCCCCCC
InChI	InChI=1S/C32H68NO6P/c1-6-8-10-12-14-16-18-20-22-24-27-36-30-32(31-39-40(34,35)38-29-26-33(3,4)5)37-28-25-23-21-19-17-15-13-11-9-7-2/h32H,6-31H2,1-5H3/t32-/m1/s1
InChIKey	MIOIPSRFEJKMJG-JGCGQSQUSA-N
Purity	>99%
Appearance	Powder
Shelf Life	1 Year
Storage	Store at -20°C
Exact Mass	593.478
Hygroscopic	No
Light Sensitive	No
Percent Composition	C 64.72%, H 11.54%, N 2.36%, O 16.16%, P 5.22%

12:0 Diether PC, a synthetic lipid renowned for its unique properties, finds widespread application in bioscience research. Here are four key applications of 12:0 Diether PC:

Liposome Formation: Serving as a cornerstone in drug delivery studies, 12:0 Diether PC is a crucial component in crafting liposomes. These vesicles encapsulate therapeutic agents, augmenting their stability and facilitating precise delivery to target cells. Researchers leverage 12:0 Diether PC to fine-tune the membrane properties of liposomes, such as fluidity and permeability, enhancing their efficacy as carriers of therapeutic payloads.

Membrane Protein Studies: Central to the field of membrane protein research, 12:0 Diether PC plays a pivotal role in reconstituting membrane proteins within artificial lipid bilayers. This synthetic lipid aids in constructing robust bilayers that closely mimic the native environment of membrane proteins. By embedding membrane proteins in these bilayers, scientists can probe into their structural intricacies, functional characteristics, and intricate interactions within a controlled experimental setup.

Model Membrane Systems: Researchers employ 12:0 Diether PC to engineer model membrane systems for investigating lipid-lipid and lipid-protein interactions. These systems serve as invaluable tools in unraveling the biophysical attributes of cell membranes, including phase behavior and elasticity. The insights gained from these model systems are indispensable for deciphering the underlying mechanisms governing various membrane-related processes and diseases, paving the way for novel therapeutic interventions.

Vaccine Development: In the realm of immunology and vaccine research, 12:0 Diether PC emerges as a key ingredient in lipid-based adjuvant formulation. By integrating this lipid into vaccine adjuvants, the immune response can be potentiated, leading to heightened protection against infectious diseases. This application holds immense promise in bolstering the efficacy and longevity of vaccines.

References

1. Cavagnero S, Dyson HJ, Wright PE. Improved low pH bicelle system for orienting macromolecules over a wide temperature range. J Biomol NMR. 1999 Apr;13(4):387-91. doi: 10.1023/a:1008360022444. PMID: 10353198. PubMed ID: 10353198.

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