mPEG-MAL

Synonyms: Methoxy polyethylene glycol-maleimide; Methoxy polyethylene glycol-MAL; Methoxy-PEG-MAL; Methoxy-PEG-maleimide<

Methoxy polyethylene glycol-maleimide (mPEG-MAL) is a linear monofunctional methyl ether PEG with reactive maleimide group. Mal selectively reacts with free mercaptan, sulfhydryl or sulfhydryl groups through Michael addition to form stable carbon sulfur bonds. It is usually viscous or solid, soluble in organic solvents and water, and can be stored for a long time at - 20℃. mPEG-MAL can be used to modify proteins, peptides and other materials or small molecules containing sulfhydryl groups. It is easy to form stable thioether bond with sulfhydryl group in pH 6.5-7.5. It is an excellent surface modification material. It can modify a variety of drugs, such as protein drugs, peptide compounds, organic small molecule drugs and so on. Similarly, it is also widely used in PEG modification of biological nanomaterials.

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