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Tos-PEG1-THP

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Category	Tos-PEGn-THP
Catalog NO.	BPG-3473
Product Name	Tos-PEG1-THP
CAS	65338-95-6
Molecular Formula	C14H20O5S
Molecular Weight	300.37

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Product Information

Description	Tos-PEG1-THP is a PEG linker with a tosyl moiety and THP protecting group. It is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media. THP is an alcohol protection group that can be removed under acidic conditions. Tosyl is an excellent leaving group for nucleophilic substitution reaction.
Synonyms	Ethanol, 2-[(tetrahydro-2H-pyran-2-yl)oxy]-, 4-methylbenzenesulfonate; 2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl 4-methylbenzenesulfonate
IUPAC Name	4-methylbenzenesulfonic acid;2-(oxan-2-yloxy)ethanol
Canonical SMILES	CC1=CC=C(C=C1)S(=O)(=O)O.C1CCOC(C1)OCCO
InChI	InChI=1S/C7H8O3S.C7H14O3/c1-6-2-4-7(5-3-6)11(8,9)10;8-4-6-10-7-3-1-2-5-9-7/h2-5H,1H3,(H,8,9,10);7-8H,1-6H2
InChIKey	KBUHOFOWJHCHEG-UHFFFAOYSA-N
Boiling Point	447.3±45.0 °C at 760 mmHg
Purity	≥95%
Density	1.2±0.1 g/cm3
Storage	Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)
Exact Mass	318.11370959

References

Kamimura, A. et al. Agric. Biol. Chem., 37, 2037 (1973).

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