THP-PEG6-alcohol
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| Category | Small-molecule Heterobifunctional PEG |
| Catalog NO. | BPG-2037 |
| Product Name | THP-PEG6-alcohol |
| CAS | 42607-87-4 |
| Molecular Formula | C17H34O8 |
| Molecular Weight | 366.45 |
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| Description | THP-PEG6-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. THP-PEG6-OH is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
| Synonyms | OH-PEG6-THP; HO-PEG6-THP; THP-PEG7; THP-PEG6-OH; 3,6,9,12,15-Pentaoxaheptadecan-1-ol, 17-[(tetrahydro-2H-pyran-2-yl)oxy]-; 17-((Tetrahydro-2H-pyran-2-yl)oxy)-3,6,9,12,15-pentaoxaheptadecan-1-ol |
| IUPAC Name | 2-[2-[2-[2-[2-[2-(oxan-2-yloxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol |
| Canonical SMILES | C1CCOC(C1)OCCOCCOCCOCCOCCOCCO |
| InChI | InChI=1S/C17H34O8/c18-4-6-19-7-8-20-9-10-21-11-12-22-13-14-23-15-16-25-17-3-1-2-5-24-17/h17-18H,1-16H2 |
| InChIKey | ABJWCLPYMPRGRB-UHFFFAOYSA-N |
| Boiling Point | 469.0±45.0 °C at 760 mmHg |
| Purity | ≥95% |
| Density | 1.10±0.1 g/cm3 (Predicted) |
| Solubility | Soluble in DMSO (10 mm) |
| Related CAS | 92417-25-9 (polymer) 301295-36-3 (polymer) |
| Appearance | Solid |
| Shelf Life | -20°C 3 years powder; -80°C 2 years in solvent |
| Storage | Store at 2-8°C |
| LogP | 0.90320 |
|
THP-PEG6-alcohol, a versatile chemical compound with applications in bioconjugation and drug delivery systems, serves as a cornerstone of innovation in these fields. Here are four key applications presented with high perplexity and burstiness: Drug Delivery Systems: THP-PEG6-alcohol plays a pivotal role in the realm of drug delivery systems, where it is harnessed to modify drug molecules, enhancing their solubility and stability within biological systems. By conjugating drugs with PEG, it extends their circulation time in the bloodstream and mitigates immunogenic reactions. This strategic conjugation leads to enhanced therapeutic outcomes and decreased side effects, propelling advancements in medical treatments. Surface Modification: A cornerstone of biotechnology, THP-PEG6-alcohol finds application in surface modification of medical devices and biomaterials to elevate their biocompatibility. The PEGylation process creates a hydrophilic shield around surfaces, diminishing protein adsorption and cellular adherence. This transformative process is integral in augmenting the durability and efficacy of implants and sensors, fostering sustainable progress in medical technology. Bioconjugation: At the heart of bioconjugation techniques, THP-PEG6-alcohol serves as a vital linker for connecting biomolecules like proteins and peptides to diverse carriers or surfaces. This modulated attachment is fundamental for the advancement of targeted drug delivery systems, diagnostic tools, and therapeutic agents. It facilitates precise bonding and controlled release of biologically active compounds, driving forward the frontier of personalized medicine. Protein Studies: Within the realm of protein studies, THP-PEG6-alcohol emerges as a game-changer in optimizing protein purification processes and stability assessments. PEGylation shields proteins from denaturation and degradation during handling and storage, preserving their integrity. Moreover, it enables the formulation of protein-based reagents with enhanced solubility and functional stability, revolutionizing research in molecular biology and biotechnology. |
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Technical Information
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- How to Perform Polyethylene Glycol (PEG) Modification?
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- Introduction of Polyethylene Glycol (PEG)
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- Polyethylene Glycol (PEG) Modifier Selection Guide
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Industry News
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- FDA approved PEGylated Products
- FDA-Approved Antibody-Drug Conjugates up to 2024
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- Lipid Classification and Drug Delivery Systems
- Lipid Formulations: Key Absorption-Enhancing Technologies in New Drug Development
- Lipid-Drug Conjugates (LDCs) for Nanoparticle Drug Delivery
- Liposome in Drug Delivery
- Overview of Liposome Preparation Process
- PEG in Pharmaceutical Preparations (I): Solvents, Lubricants, Adhesives and More
- PEG in Pharmaceutical Preparations (II): Stabilizers, Plasticizers and Modification Materials
- PEG Linkers in Antibody Drug Conjugates and PROTACs
- PEG-DSPE Block Copolymers and Their Derivatives
- PEGylated Drugs: Definition, Structure, Classification and Benefits
- PEGylated RGD Peptides: A Promising Tool for Targeted Drug Delivery
- Pharmacokinetics and Bioanalysis of PEGylated Drugs
- Polyethylene Glycol (PEG) Modified Targeting Nanomaterials
- Preparation Method of PEG Hydrogel
- The PROTAC Technology in Drug Development
- Vaccines: Definition, History, Ingredients, Types and Mechanism of Action
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- What are Lipid Nanoparticles and Their Applications?
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- What are Lipids?
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PEGylation of Peptides
and Proteins
Reduce the Immunogenicity of Peptide/Protein Drugs
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APPLICATIONS
PEG linkers For Drug
Improved Circulation Half-Life
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