NH2-PEG11-IC

NH2-PEG11-IC is a bifunctional polyethylene glycol (PEG) linker often used in bioconjugation and drug delivery systems. Here are some key applications of NH2-PEG11-IC:

Drug Delivery Systems: NH2-PEG11-IC is commonly used to modify drug molecules or therapeutic agents to improve their pharmacokinetics and reduce immunogenicity. By attaching PEG molecules to drugs, the modified compounds exhibit increased solubility and extended circulation time in the bloodstream. This enhances the efficacy and safety profiles of various therapeutic agents, including anticancer drugs and biologics.

Bioconjugation: NH2-PEG11-IC serves as an essential tool in the creation of bioconjugates, where it acts as a flexible spacer between biomolecules. This linker is often used to attach enzymes, antibodies, or peptides to solid supports or other biomolecules without compromising their functional activity. The PEGylation process helps maintain the stability and activity of biomolecules under experimental or therapeutic conditions.

Diagnostic Imaging: In the field of diagnostic imaging, NH2-PEG11-IC is used to conjugate imaging agents such as contrast dyes to targeting molecules like antibodies or peptides. This ensures that the imaging agents are specifically delivered to target tissues or cells, improving the accuracy of imaging techniques such as MRI or PET scans. These PEGylated imaging agents provide clearer and more precise images for diagnostic purposes.

Surface Modification: NH2-PEG11-IC is utilized in surface modification applications to impart biocompatibility and anti-fouling properties to various materials. For instance, it can be used to coat medical devices, implants, or biosensors, reducing protein adsorption and cellular adhesion. This surface modification technique helps prevent adverse immune responses and enhances the performance and longevity of biomedical devices.