| Category | Small-molecule Carboxylic Acid PEG |
| Molecular Formula | C52H77N3O19 |
| Molecular Weight | 1048.2 |
| Shipping | Ambient temperature |
| Storage | -20°C |
N-(DBCO-PEG4-carbonyl)-N-bis(PEG4-acid)
N-(DBCO-PEG4-carbonyl)-N-bis(PEG4-acid) is a reagent combining two carboxylic acids and a DBCO moiety. The carboxylic acids can be reacted with primary amines in the presence of an activator such as HATU or EDC to form stable and water-soluble amide bonds, while the DBCO moiety is used in click chemistry with azides. The inclusion of a tertiary amide and PEG linkers improves this molecule's aqueous solubility.
Structure of N-(DBCO-PEG4-carbonyl)-N-bis(PEG4-acid)
Ordering Information
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- Specification
- Key Product Attributes
- Reaction & Conjugation Properties
| Purity | 0.98 |
| PEGType | Multi-Arm PEG |
| PEGArchitecture | 3-Arm |
| Functionality | Heterobifunctional |
| ReactiveToward | Azides; Primary Amines (after activation) |
| ReactionChemistry | SPAAC Click Chemistry; Carbodiimide-Mediated Amide Coupling (EDC/NHS) |
| BiomoleculeCompatibility | Click-Handle-Modified Proteins / Peptides; Click-Handle-Modified Antibodies; Click-Handle-Modified Oligonucleotides; Small Molecules / Probes; Proteins / Antibodies; Peptides; Amine-Modified Oligonucleotides |
| ResearchUse | Copper-Free Azide–Cyclooctyne Ligation; Carboxyl-to-Amine Coupling after Activation; Amide Bond Formation |
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