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Mal-PEG1-NHS ester

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Category	Small-molecule Heterobifunctional PEG
Catalog NO.	BPG-1933
Product Name	Mal-PEG1-NHS ester
CAS	1807518-72-4
Molecular Formula	C13H14N2O7
Molecular Weight	310.26

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Description	Mal-PEG1-NHS ester is a cleavable and PEG-based ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Synonyms	Mal-PEG1-SPA; Maleimide-PEG1-Succinimidyl Propionate; 2,5-Dioxopyrrolidin-1-yl 3-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)propanoate; Propanoic acid, 3-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester; 1-(2-{3-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-3-oxopropoxy}ethyl)-1H-pyrrole-2,5-dione; 1H-Pyrrole-2,5-dione, 1-[2-[3-[(2,5-dioxo-1-pyrrolidinyl)oxy]-3-oxopropoxy]ethyl]-
IUPAC Name	(2,5-dioxopyrrolidin-1-yl) 3-[2-(2,5-dioxopyrrol-1-yl)ethoxy]propanoate
Canonical SMILES	C1CC(=O)N(C1=O)OC(=O)CCOCCN2C(=O)C=CC2=O
InChI	InChI=1S/C13H14N2O7/c16-9-1-2-10(17)14(9)6-8-21-7-5-13(20)22-15-11(18)3-4-12(15)19/h1-2H,3-8H2
InChIKey	AMRJPIJPLBUEHO-UHFFFAOYSA-N
Boiling Point	488.4±55.0°C (Predicted)
Flash Point	249.2±31.5 °C
Purity	≥95%
Density	1.48±0.1 g/cm3 (Predicted)
Solubility	Soluble in DCM, DMSO
Related CAS	357277-60-2 (polymer) 1303508-68-0 (polymer) 1520853-90-0 (polymer) 1802486-72-1 (polymer)
Appearance	White Solid
Shelf Life	-20°C 3 years powder; -80°C 2 years in solvent
Storage	Store at 2-8°C
Vapor Pressure	0.0±1.2 mmHg at 25°C
LogP	-1.89

Mal-PEG1-NHS ester, a versatile chemical reagent pivotal in bioconjugation and polymer chemistry, finds diverse applications. Here are four key applications narrated with high perplexity and burstiness:

Protein Cross-Linking: Mal-PEG1-NHS ester serves as an indispensable tool for cross-linking proteins, a process crucial in stabilizing protein complexes or linking proteins to diverse molecules. This reagent, adept at reacting with primary amines on proteins, forms stable amide bonds. The inclusion of a polyethylene glycol (PEG) spacer in the structure aids in maintaining protein functionality by averting steric hindrance.

Drug Delivery: Within the realm of drug delivery systems, Mal-PEG1-NHS ester plays a pivotal role in conjugating therapeutic agents to targeting molecules, such as antibodies, thereby heightening their specificity and efficacy. The process of PEGylation, facilitated by this reagent, extends the circulation time of the drug while diminishing immunogenicity. This dual effect results in superior therapeutic outcomes and mitigated side effects, marking a significant advance in the field.

Biomaterial Functionalization: Leveraging Mal-PEG1-NHS ester enables the functionalization of biomaterial surfaces, thereby enhancing their biocompatibility and functionality. By tethering bioactive molecules, like peptides or antibodies, to the surface, cell adhesion, proliferation, and differentiation can be substantially improved. This innovative approach proves invaluable in applications within tissue engineering and regenerative medicine, underscoring its importance in advancing biotechnological solutions.

Biosensor Development: Within the domain of biosensor development, Mal-PEG1-NHS ester emerges as an essential component for immobilizing biomolecules onto sensor surfaces, facilitating specific and sensitive detection of target analytes. The presence of a PEG spacer imparts flexibility and reduces non-specific binding, culminating in heightened accuracy and reliability in sensor performance. This precision-driven technique holds immense promise in enhancing biosensing technologies for diverse applications.

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