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Hydroxy-PEG8-propionic acid

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Category	Small-molecule Heterobifunctional PEG
Catalog NO.	BPG-2164
Product Name	Hydroxy-PEG8-propionic acid
CAS	937188-60-8
Molecular Formula	C19H38O11
Molecular Weight	442.50

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Description	HO-PEG8-CH2CH2COOH is a polyethylene glycol (PEG)-based PROTAC linker. HO-PEG8-CH2CH2COOH can be used in the synthesis of a series of PROTACs.
Synonyms	OH-PEG8-COOH; HO-PEG8-Propionic acid; HO-PEG8-CH2CH2COOH; Hydroxy-PEG8-acid; 1-Hydroxy-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oic acid; α-hydroxy-ω-propionic acid octaethylene glycol; 3-[(23-Hydroxy-3,6,9,12,15,18,21-heptaoxatricos-1-yl)oxy]propanoic acid; 3,6,9,12,15,18,21,24-Octaoxaheptacosan-27-oic acid, 1-hydroxy-
IUPAC Name	3-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
Canonical SMILES	C(COCCOCCOCCOCCOCCOCCOCCOCCO)C(=O)O
InChI	InChI=1S/C19H38O11/c20-2-4-24-6-8-26-10-12-28-14-16-30-18-17-29-15-13-27-11-9-25-7-5-23-3-1-19(21)22/h20H,1-18H2,(H,21,22)
InChIKey	BGBLNDCLYGWOKM-UHFFFAOYSA-N
Boiling Point	554.3±50.0 °C at 760 mmHg
Purity	>98%
Density	1.1±0.1 g/cm3
Appearance	Colorless Liquid
Storage	Store at 2-8°C

Hydroxy-PEG8-propionic acid, a versatile chemical compound with diverse applications in scientific and medical domains. Here are four key applications of Hydroxy-PEG8-propionic acid presented with high perplexity and burstiness:

Drug Delivery Systems: In the realm of drug delivery systems, Hydroxy-PEG8-propionic acid plays a pivotal role in designing advanced systems to enhance the solubility and stability of therapeutic agents. By conjugating this compound to drug molecules, it prolongs their circulation time and mitigates immunogenicity. This innovative approach results in more effective and targeted drug delivery to diseased tissues, revolutionizing the field of medication administration.

Bioconjugation: Harnessing bioconjugation techniques, Hydroxy-PEG8-propionic acid serves as a crucial element for linking proteins, peptides, or other biomolecules to a myriad of surfaces or carriers. This linkage facilitates the development of diagnostic tools and biosensors with heightened sensitivity and specificity. The compound's reactive groups enable precise and durable conjugation, essential for ensuring the reliability of biotechnological applications in a rapidly evolving scientific landscape.

Surface Modification: Widely employed in surface modification, Hydroxy-PEG8-propionic acid is a key component in enhancing the surfaces of medical devices and implants. By coating surfaces with this compound, a hydrophilic barrier is created, effectively reducing protein adsorption and cell adhesion. This proactive measure minimizes the risk of biofouling and thrombosis, ultimately enhancing the biocompatibility and lifespan of medical implants, setting new standards in medical device technology.

Pharmaceutical Research: Delving into the realm of pharmaceutical research, Hydroxy-PEG8-propionic acid assumes a pivotal role as a versatile spacer or linker in prodrug synthesis. By integrating this compound, researchers gain precise control over the drug release rate and activation within the body. This controlled release mechanism holds the promise of improved therapeutic outcomes and reduced side effects, showcasing the potential for groundbreaking advancements in pharmaceutical treatment protocols.

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