Hexaethylene glycol

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Category	Small-molecule Polyethylene Glycol
Catalog NO.	BPG-1890
Product Name	Hexaethylene glycol
CAS	2615-15-8
Molecular Formula	C12H26O7
Molecular Weight	282.33

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Description	Hexaethylene Glycol (CAS# 2615-15-8) is part of a leaf extract (Murdannia Bracteata) which exhibits antioxidant, antimicrobial and anti-cancer properties. It also shows potential application as functional hydraulic fluids.
Synonyms	HO-PEG6-OH; 2,2'-[oxybis(oxy-2,1-ethanediyloxy-2,1-ethanediyloxy)]bis Ethanol; Hexagol; Hexaoxyethylene Glycol; NSC 201209; 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol; Ethanol, 2,2'-(oxybis(ethyleneoxyethyleneoxy))di-; 2-[2-(2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethan-1-ol; Ethanol, 2, 2'-[oxybis(oxy-2,1-ethanediyloxy-2,1-ethanediyloxy)]bis-
IUPAC Name	2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol
Canonical SMILES	C(COCCOCCOCCOCCOCCO)O
InChI	InChI=1S/C12H26O7/c13-1-3-15-5-7-17-9-11-19-12-10-18-8-6-16-4-2-14/h13-14H,1-12H2
InChIKey	IIRDTKBZINWQAW-UHFFFAOYSA-N
Boiling Point	217°C at 4 mmHg
Melting Point	5-7°C
Purity	>98%
Density	1.127 g/mL at 25°C
Solubility	Soluble in Chloroform (Slightly), Methanol (Slightly)
Appearance	Pale Yellow or Colorless Liquid
Application	Hexaethylene Glycol is part of a leaf extract (Murdannia Bracteata) which exhibits antioxidant, antimicrobial and anti-cancer properties. It also shows potential application as functional hydraulic fluids.
Storage	Store at 2-8°C
Exact Mass	282.16785316
LogP	-0.94600
Pictogram(s)	Irritant
Signal	Warning
Precautionary Statement Codes	P264+P265, P280, P305+P351+P338, and P337+P317

Hexaethylene glycol, a remarkably versatile compound with applications spanning various scientific domains, is the focus of the following four key applications depicted with a high degree of perplexity and burstiness:

Pharmaceutical Formulations: Embedded within pharmaceutical formulations, hexaethylene glycol operates as an excipient, elevating the solubility and stability of active pharmaceutical ingredients (APIs). Acting as a solubilizing agent for poorly water-soluble drugs, it amplifies their bioavailability and therapeutic potency. Moreover, as a stabilizer in diverse dosage forms like oral suspensions and injectable solutions, it upholds the integrity of formulations, ensuring optimal efficacy.

Polymer Science: Within the realm of polymer science, hexaethylene glycol serves as a foundational building block for synthesizing polyethylene glycol (PEG) and its derivatives. The inclusion of PEG chains in biomolecules through PEGylation enhances the pharmacokinetics and biocompatibility of therapeutic agents, revolutionizing drug delivery systems. This strategic application of PEGylation prolongs circulation time and alleviates immunogenic responses, reshaping targeted drug delivery methodologies.

Chemical Synthesis: Widely embraced in chemical synthesis, hexaethylene glycol assumes the dual roles of solvent and reagent owing to its exceptional capacity to dissolve a wide array of organic and inorganic compounds. Its versatility in chemical reactions and processes renders it indispensable in synthesizing polymers, resins, and other specialized chemicals. As a preferred reaction medium, it facilitates diverse chemical transformations with precision and efficiency, underpinning various chemical synthesis endeavors.

Biotechnology: Embraced within the realm of biotechnology, hexaethylene glycol emerges as a key player in protein purification and stabilization processes. Employed in affinity chromatography and assorted separation techniques, it enables the precise isolation of proteins and biomolecules with exceptional specificity. Its distinctive properties contribute to preserving protein structure and function during purification procedures, ensuring elevated yield and activity levels for subsequent applications, thereby reinforcing its significance in biotechnological advancements.

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