Fmoc-NH-PEG12-alcohol

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Category	Fmoc-NH-PEGn-alcohol
Catalog NO.	BPG-1693
Product Name	Fmoc-NH-PEG12-alcohol
Molecular Formula	C39H61NO14
Molecular Weight	767.91

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Description	Fmoc-NH-PEG12-alcohol is a PEG linker containing a Fmoc-protected amine and a terminal hydroxyl group. The Fmoc group can be deprotected under the basic condition to obtain the free amine which can be used for further conjugations. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The hydrophilic PEG spacer increases solubility in aqueous media.
Synonyms	Fmoc-PEG12-alcohol; Fmoc-N-amido-PEG12-alcohol; Fmoc-NH-PEG12-OH; (9H-fluoren-9-yl)methyl (35-hydroxy-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontyl)carbamate
IUPAC Name	9H-fluoren-9-ylmethyl N-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]carbamate
Canonical SMILES	O=C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO
InChI	InChI=1S/C39H61NO14/c41-10-12-44-14-16-46-18-20-48-22-24-50-26-28-52-30-32-53-31-29-51-27-25-49-23-21-47-19-17-45-15-13-43-11-9-40-39(42)54-33-38-36-7-3-1-5-34(36)35-6-2-4-8-37(35)38/h1-8,38,41H,9-33H2,(H,40,42)
InChIKey	KCHLFUQHTVZTOG-UHFFFAOYSA-N
Purity	≥95%
Storage	Store at 2-8°C

Fmoc-NH-PEG12-alcohol, a versatile reagent widely utilized in peptide and polymer chemistry, finds diverse applications in various fields. Here are four key applications of Fmoc-NH-PEG12-alcohol depicted with elevated levels of perplexity and burstiness:

Peptide Synthesis: Serving as a pivotal spacer molecule in solid-phase peptide synthesis, Fmoc-NH-PEG12-alcohol aids in the elongation of peptide chains, introducing crucial flexibility between amino acid residues. This reagent plays a vital role in crafting intricate peptide structures with enhanced solubility and stability, pushing the boundaries of peptide chemistry to new heights.

Drug Delivery Systems: Positioned at the forefront of drug delivery system development, this compound acts as a crucial linker connecting therapeutic agents to polymer carriers. The incorporation of the PEG12 moiety boosts the solubility and biocompatibility of drug conjugates, enabling controlled drug release and targeted delivery, thereby elevating therapeutic efficacy to unprecedented levels.

Hydrogel Formation: Delving into the synthesis of hydrogels for biomedical applications, Fmoc-NH-PEG12-alcohol offers unparalleled versatility. These customizable hydrogels cater to specific needs such as wound healing, tissue engineering, and drug delivery, aided by the mechanical reinforcement and biocompatibility enhancements brought forth by the PEG12 spacer, propelling the field of hydrogel engineering into uncharted territories.

Bioconjugation: In the intricate realm of bioconjugation techniques, the utilization of Fmoc-NH-PEG12-alcohol heralds new possibilities. This reagent plays a pivotal role in attaching biomolecules to surfaces or other molecules, leveraging the flexibility and steric hindrance reduction provided by the PEG12 linker to enhance the functionalization of nanoparticles, biosensors, and diagnostic assays, thereby elevating the sensitivity and specificity of biotechnological applications to unprecedented levels of precision and efficiency.

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