Fmoc-NH-PEG10-alcohol

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Category	Fmoc-NH-PEGn-alcohol
Catalog NO.	BPG-1694
Product Name	Fmoc-NH-PEG10-alcohol
Molecular Formula	C35H53NO12
Molecular Weight	679.80

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Description	Fmoc-NH-PEG10-alcohol is a PEG linker containing a Fmoc-protected amine and a terminal hydroxyl group. The Fmoc group can be deprotected under the basic condition to obtain the free amine which can be used for further conjugations. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The hydrophilic PEG spacer increases solubility in aqueous media.
Synonyms	Fmoc-PEG10-alcohol; Fmoc-N-amido-PEG10-alcohol; Fmoc-NH-PEG10-OH; (9H-fluoren-9-yl)methyl (29-hydroxy-3,6,9,12,15,18,21,24,27-nonaoxanonacosyl)carbamate
IUPAC Name	9H-fluoren-9-ylmethyl N-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]carbamate
Canonical SMILES	O=C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO
InChI	InChI=1S/C35H53NO12/c37-10-12-40-14-16-42-18-20-44-22-24-46-26-28-47-27-25-45-23-21-43-19-17-41-15-13-39-11-9-36-35(38)48-29-34-32-7-3-1-5-30(32)31-6-2-4-8-33(31)34/h1-8,34,37H,9-29H2,(H,36,38)
InChIKey	NQRMPQGYEKKAHK-UHFFFAOYSA-N
Purity	≥95%
Storage	Store at 2-8°C

Fmoc-NH-PEG10-alcohol is a functionalized polyethylene glycol (PEG) compound used in various biotechnological and pharmaceutical applications. Here are some key applications of Fmoc-NH-PEG10-alcohol:

Peptide Synthesis: Fmoc-NH-PEG10-alcohol serves as a valuable reagent in solid-phase peptide synthesis (SPPS). The Fmoc group protects the amine functionality during peptide elongation, while the PEG moiety increases solubility and enhances peptide purification. This enables the efficient synthesis of long and complex peptides with high purity.

Drug Delivery: In drug delivery systems, Fmoc-NH-PEG10-alcohol can be utilized to improve the pharmacokinetic properties of therapeutic agents. PEGylation, the process of attaching PEG chains to drugs, enhances their solubility, stability, and circulation time in the bloodstream. This results in improved drug efficacy and reduced immunogenicity.

Bioconjugation: Fmoc-NH-PEG10-alcohol is used in bioconjugation techniques to link bioactive molecules, such as antibodies, proteins, or small molecules, to PEG chains. The Fmoc group allows for site-specific conjugation, while the PEG spacer increases the solubility and reduces steric hindrance. This helps in the creation of bio-conjugates with enhanced stability and bioactivity for diagnostic and therapeutic applications.

Surface Modification: Fmoc-NH-PEG10-alcohol can be used for the surface modification of biomaterials and nanoparticles. The PEG chains form a hydrophilic shell that reduces protein adsorption and minimizes immune recognition. This results in improved biocompatibility and circulation time for materials used in biomedical applications, such as implants, sensors, and drug delivery vehicles.

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