DSPE-PEG-Biotin sodium salt

Name: DSPE-PEG-Biotin sodium salt
Brand: BOC Sciences
Rating: 5 (1 reviews)

CAS No.: 385437-57-0

Cat No.: BPG-2971

Purity: ≥95%

4.5

DSPE-PEG-Biotin sodium salt is a heterobifunctional PEGylated phospholipid consisting of a DSPE lipid anchor, a PEG spacer, and a biotin functional group, with the phosphate group present as a sodium salt. The DSPE moiety anchors into lipid bilayers, the PEG chain provides stealth properties and extends circulation half-life, while the biotin group enables specific binding to streptavidin/avidin conjugates. It is widely used for liposome and lipid nanoparticle surface functionalization, targeted drug delivery, and bioconjugation applications. The compound allows post-insertion of streptavidin-conjugated targeting ligands, antibodies, or imaging agents into preformed liposomes, facilitating the preparation of immunoliposomes and targeted nanocarriers for cancer therapy and diagnostic imaging.

Category	Functionalized PEG Lipids
Molecular Formula	(C2H4O)nC54H100N4NaO12PS
Appearance	Off-white/white solid or liquid.
Shipping	Shipped under RT.
Storage	Store at -20 °C

Structure of 385437-57-0

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Specification
References

Synonyms	Poly(oxy-1,2-ethanediyl), α-[(9R)-6-hydroxy-6-oxido-1,12-dioxo-9-[(1-oxooctadecyl)oxy]-5,7,11-trioxa-2-aza-6-phosphanonacos-1-yl]-ω-[2-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]ethoxy]-, sodium salt (1:1); Poly(oxy-1,2-ethanediyl), α-[(9R)-6-hydroxy-6-oxido-1,12-dioxo-9-[(1-oxooctadecyl)oxy]-5,7,11-trioxa-2-aza-6-phosphanonacos-1-yl]-ω-[2-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]ethoxy]-, monosodium salt; α-[(9R)-6-Hydroxy-6-oxido-1,12-dioxo-9-[(1-oxooctadecyl)oxy]-5,7,11-trioxa-2-aza-6-phosphanonacos-1-yl]-ω-[2-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]ethoxy]poly(oxy-1,2-ethanediyl) sodium salt (1:1); 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[biotinyl(polyethylene glycol)-2000]; DSPE-PEG-Biotin sodium salt; Laysan Bio DSPE-PEG-biotin
Purity	≥95%
Solubility	Soluble in chloroform, warm water (for powder form).
RelatedCAS	740794-01-8 (free acid) 474964-24-4 (ammonium salt)
ShelfLife	1 Year.
ExactMass	3014.867
Hygroscopic	Yes
LightSensitive	No
PercentComposition	C 56.54%, H 9.36%, N 2.32%, O 29.70%, P 1.03%, S 1.06%