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DSPE-PEG (2000) Biotin

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Category	Functionalized PEG Lipids
Catalog NO.	BPG-2971
Product Name	DSPE-PEG (2000) Biotin
CAS	385437-57-0
Molecular Formula	C142H280N5O56PS
Molecular Weight	3016.82

Scheme Design
Custom Synthesis
cGMP Manufacturing
Quality Assurance

Product Information
Application
References
Documents
Reviews

Product Information

Description	DSPE-PEG(2000) Biotin has been used in the generation of biotinylated liposome.
Synonyms	1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[biotinyl(polyethylene glycol)-2000] (ammonium salt)
IUPAC Name	azanium;2-[2-[(Z)-2-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]ethenyl]peroxyperoxyperoxyperoxyperoxyperoxyperoxyperoxyperoxyperoxyperoxyperoxyperoxyperoxyperoxyperoxyperoxyperoxyperoxyperoxyperoxyperoxyethoxycarbonylamino]ethyl [(2R)-2,3-di(octadecanoyloxy)propyl] phosphate;ethene
Canonical SMILES	CCCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)([O-])OCCNC(=O)OCCOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOC=CNC(=O)CCCCC1C2C(CS1)NC(=O)N2)OC(=O)CCCCCCCCCCCCCCCCC.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.[NH4+]
InChI	InChI=1S/C56H103N4O56PS.43C2H4.H3N/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-37-52(62)69-45-48(74-53(63)38-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2)46-73-117(66,67)72-42-40-58-56(65)68-43-44-71-76-78-80-82-84-86-88-90-92-94-96-98-100-102-104-106-108-110-112-114-116-115-113-111-109-107-105-103-101-99-97-95-93-91-89-87-85-83-81-79-77-75-70-41-39-57-51(61)36-34-33-35-50-54-49(47-118-50)59-55(64)60-54;431-2;/h39,41,48-50,54H,3-38,40,42-47H2,1-2H3,(H,57,61)(H,58,65)(H,66,67)(H2,59,60,64);431-2H2;1H3/b41-39-;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;/t48-,49+,50+,54+;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;/m1............................................/s1
InChIKey	WPJAGUQFRZGKOO-ZNOVEVEBSA-N
Purity	>90%
Solubility	Soluble in chloroform, warm water (for powder form).
Appearance	Off-white/white solid or liquid.
Shelf Life	1 Year.
Storage	Store at -20°C.
Exact Mass	3014.867
Hygroscopic	Yes
Light Sensitive	No
Percent Composition	C 56.54%, H 9.36%, N 2.32%, O 29.70%, P 1.03%, S 1.06%

References

1. Bourn MD, Batchelor DVB, Ingram N, McLaughlan JR, Coletta PL, Evans SD, Peyman SA. High-throughput microfluidics for evaluating microbubble enhanced delivery of cancer therapeutics in spheroid cultures. J Control Release. 2020 Jun 17;326:13-24. doi: 10.1016/j.jconrel.2020.06.011. Epub ahead of print. PMID: 32562855. PubMed ID: 32562855.
2. Beekers I, Mastik F, Beurskens R, Tang PY, Vegter M, van der Steen AFW, de Jong N, Verweij MD, Kooiman K. High-Resolution Imaging of Intracellular Calcium Fluctuations Caused by Oscillating Microbubbles. Ultrasound Med Biol. 2020 May 10:S0301-5629(20)30145-9. doi: 10.1016/j.ultrasmedbio.2020.03.029. Epub ahead of print. PMID: 32402676. PubMed ID: 32402676.
3. Bohr SS, Thorlaksen C, Kühnel RM, Günther Pomorski T, Hatzakis NS. Label free fluorescence quantification of hydrolytic enzyme activity on native substrates reveal how lipase function depends on membrane curvature. Langmuir. 2020 May 21. doi: 10.1021/acs.langmuir.0c00787. Epub ahead of print. PMID: 32437165. PubMed ID: 32437165.
4. Langeveld SAG, Schwieger C, Beekers I, Blaffert J, van Rooij T, Blume A, Kooiman K. Ligand Distribution and Lipid Phase Behavior in Phospholipid-Coated Microbubbles and Monolayers. Langmuir. 2020 Mar 31;36(12):3221-3233. doi: 10.1021/acs.langmuir.9b03912. Epub 2020 Mar 18. PMID: 32109064. PubMed ID: 32109064.
5. Beekers I, Vegter M, Lattwein KR, Mastik F, Beurskens R, van der Steen AFW, de Jong N, Verweij MD, Kooiman K. Opening of endothelial cell-cell contacts due to sonoporation. J Control Release. 2020 Apr 1;322:426-438. doi: 10.1016/j.jconrel.2020.03.038. Epub ahead of print. PMID: 32246975. PubMed ID: 32246975.
6. Khan MS, Kim JS, Hwang J, Choi Y, Lee K, Kwon Y, Jang J, Yoon S, Yang CS, Choi J. Effective delivery of mycophenolic acid by oxygen nanobubbles for modulating immunosuppression. Theranostics. 2020 Mar 4;10(9):3892-3904. doi: 10.7150/thno.41850. PMID: 32226527; PMCID: PMC7086369. PubMed ID: 32226527.
7. Yin L, Masuyer G, Zhang S, Zhang J, Miyashita SI, Burgin D, Lovelock L, Coker SF, Fu TM, Stenmark P, Dong M. Characterization of a membrane binding loop leads to engineering botulinum neurotoxin B with improved therapeutic efficacy. PLoS Biol. 2020 Mar 17;18(3):e3000618. doi: 10.1371/journal.pbio.3000618. PMID: 32182233; PMCID: PMC7077807. PubMed ID: 32182233.
8. Langeveld SAG, Schwieger C, Beekers I, Blaffert J, van Rooij T, Blume A, Kooiman K. Ligand Distribution and Lipid Phase Behavior in Phospholipid-Coated Microbubbles and Monolayers. Langmuir. 2020 Mar 18. doi: 10.1021/acs.langmuir.9b03912. Epub ahead of print. PMID: 32109064. PubMed ID: 32109064.
9. Durham ND, Howard AR, Govindan R, Senjobe F, Fels JM, Diehl WE, Luban J, Chandran K, Munro JB. Real-Time Analysis of Individual Ebola Virus Glycoproteins Reveals Pre-Fusion, Entry-Relevant Conformational Dynamics. Viruses. 2020 Jan 15;12(1):E103. doi: 10.3390/v12010103. PMID: 31952255. PubMed ID: 31952255.
10. Wu B, Shang H, Liang X, Sun Y, Jing H, Han X, Cheng W. Preparation of novel targeting nanobubbles conjugated with small interfering RNA for concurrent molecular imaging and gene therapy in vivo. FASEB J. 2019 Dec;33(12):14129-14136. doi: 10.1096/fj.201900716RR. Epub 2019 Oct 26. PubMed ID: 31657628.

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