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DNP-PEG11-OH

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Category	DNP-PEGn-OH
Catalog NO.	BPG-1671
Product Name	DNP-PEG11-OH
Molecular Formula	C28H49N3O15
Molecular Weight	667.71

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Description	DNP-PEG11-OH is a PEG linker containing a dinitrophenyl and a hydroxyl group. DNP is involved in biological applications such as participating in ion transport across membranes. The hydroxyl group can react to further derivatize the compound. The hydrophilic PEG linker increases the water solubility of the compound in aqueous environments.
Synonyms	DNP-PEG11-alcohol; 32-((2,4-dinitrophenyl)amino)-3,6,9,12,15,18,21,24,27,30-decaoxadotriacontan-1-ol
IUPAC Name	2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2,4-dinitroanilino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
Canonical SMILES	O=[N+](C1=CC=C(C([N+]([O-])=O)=C1)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO)[O-]
InChI	InChI=1S/C28H49N3O15/c32-4-6-38-8-10-40-12-14-42-16-18-44-20-22-46-24-23-45-21-19-43-17-15-41-13-11-39-9-7-37-5-3-29-27-2-1-26(30(33)34)25-28(27)31(35)36/h1-2,25,29,32H,3-24H2
InChIKey	CCMWBLLTBNNQQO-UHFFFAOYSA-N
Purity	≥95%
Appearance	Pale Yellow or Colorless Oily Matter
Storage	Store at 2-8°C

DNP-PEG11-OH is a polyethylene glycol (PEG) derivative functionalized with a dinitrophenyl (DNP) group. Here are some key applications of DNP-PEG11-OH:

Immunology Research: DNP-PEG11-OH is often used for the study of immune responses, particularly in the context of creating well-defined antigens for immunization studies. The DNP moiety can act as a hapten, helping researchers investigate hapten-specific antibody production. This compound is also valuable for exploring mechanisms of allergy and immune tolerance.

Drug Delivery Systems: The PEGylation of DNP-PEG11-OH improves solubility and biocompatibility of drugs, which is crucial in developing advanced drug delivery systems. The PEG component prolongs the circulation time of therapeutic agents in the bloodstream by reducing immunogenicity and degradation. This can lead to more effective and targeted drug therapies.

Bioconjugation: DNP-PEG11-OH is employed in bioconjugation techniques to attach various biomolecules, such as proteins, antibodies, and nanoparticles, to surfaces or carrier molecules. The incorporation of PEG spacers minimizes steric hindrance and enhances the stability of bioconjugates. This application is essential in diagnostics, imaging, and therapeutic development.

Surface Functionalization: In material sciences and bioengineering, DNP-PEG11-OH is used to functionalize surfaces such as hydrogels, nanoparticles, and biosensors. The DNP group provides a covalent attachment point, while the PEG chain imparts anti-fouling properties to the surface. This leads to improved performance and longevity of biomedical devices and sensors.

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