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DNP-PEG1-COOtBu

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Category	DNP-PEGn-COOtBu
Catalog NO.	BPG-1607
Product Name	DNP-PEG1-COOtBu
Molecular Formula	C15H21N3O7
Molecular Weight	355.35

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Description	DNP-PEG1-COOtBu is a PEG linker containing DNP and t-butyl ester moieties. DNP is involved in biological pathways and participates in ion transport across membranes. The t-butyl ester can be deprotected under acidic conditions. The hydrophilic PEG linker increases water solubility of a compound in aqueous media.
Synonyms	DNP-NH-PEG1-C2-Boc; DNP-PEG1-t-butyl ester; tert-butyl 3-(2-((2,4-dinitrophenyl)amino)ethoxy)propanoate
IUPAC Name	tert-butyl 3-[2-(2,4-dinitroanilino)ethoxy]propanoate
Canonical SMILES	O=C(OC(C)(C)C)CCOCCNC1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O
InChI	InChI=1S/C15H21N3O7/c1-15(2,3)25-14(19)6-8-24-9-7-16-12-5-4-11(17(20)21)10-13(12)18(22)23/h4-5,10,16H,6-9H2,1-3H3
InChIKey	RVAGPJJBYYVOPD-UHFFFAOYSA-N
Purity	≥95%
Appearance	Pale Yellow or Colorless Oily Matter
Storage	Store at 2-8°C

DNP-PEG1-COOtBu is a multifunctional chemical linker widely used in various bioconjugation and biomedical applications. Here are some key applications of DNP-PEG1-COOtBu:

Drug Delivery Systems: DNP-PEG1-COOtBu is used to create drug delivery systems that enhance the solubility and stability of therapeutic agents. By conjugating drugs to this PEGylated linker, researchers can improve their pharmacokinetic profiles and reduce immunogenicity. This results in better efficacy and reduced side effects for a variety of treatments.

Targeted Therapies: This compound is instrumental in the development of targeted therapies where it is employed to attach therapeutic molecules to specific ligands or antibodies. By targeting diseased cells or tissues precisely, DNP-PEG1-COOtBu helps in increasing the therapeutic index and minimizing off-target effects. Such targeted delivery is crucial for treating cancers and other site-specific conditions.

Diagnostic Imaging: DNP-PEG1-COOtBu finds applications in diagnostic imaging by enabling the conjugation of imaging agents to biomolecules. This allows for the precise visualization of biological structures and processes in vivo using techniques such as MRI or PET scans. The increased specificity and reduced background noise improve the accuracy of diagnostic results.

Protein Modification: In protein engineering and research, DNP-PEG1-COOtBu is used for the chemical modification of proteins. By attaching this linker to proteins, researchers can study protein interactions, stability, and function in various environments. This is essential for the exploration of protein therapeutics and the design of novel biomolecular tools.

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