| Category | Small-molecule Carboxylic Acid PEG |
| Molecular Formula | C57H88N2O22 |
| Molecular Weight | 1153.3 |
| Shipping | Ambient temperature |
| Storage | -20°C |
DBCO-N-bis(PEG8-acid)
DBCO-N-bis(PEG8-acid) is a trifunctional molecule containing two carboxylic acids and a DBCO functional group. The DBCO is reactive towards azides in copper-free click chemistry while the carboxylic acids can be reacted with primary amines in the presence of a coupling reagent to form stable amide bonds. PEG linkers have higher aqueous solubility than their alkane counterparts, which may impact DMPK and ADME in vivo.
Structure of DBCO-N-bis(PEG8-acid)
Ordering Information
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- Specification
- Key Product Attributes
- Reaction & Conjugation Properties
| Purity | 0.98 |
| PEGType | Multi-Arm PEG |
| PEGArchitecture | 2-Arm Branched |
| Functionality | Heterobifunctional |
| ReactiveToward | Azides; Primary Amines (after activation) |
| ReactionChemistry | SPAAC Click Chemistry; Carbodiimide-Mediated Amide Coupling (EDC/NHS) |
| BiomoleculeCompatibility | Click-Handle-Modified Proteins / Peptides; Click-Handle-Modified Antibodies; Click-Handle-Modified Oligonucleotides; Small Molecules / Probes; Proteins / Antibodies; Peptides; Amine-Modified Oligonucleotides |
| ResearchUse | Copper-Free Azide–Cyclooctyne Ligation; Carboxyl-to-Amine Coupling after Activation; Amide Bond Formation |
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