COOH-PEG8-COOtBu

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Category	COOH-PEGn-COOtBu
Catalog NO.	BPG-0185
Product Name	COOH-PEG8-COOtBu
Molecular Formula	C24H46O12
Molecular Weight	526.62

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Description	COOH-PEG8-COOtBu is a PEG linker containing a t-butyl-protected carboxyl group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The t-butyl-protected carboxyl group can be deprotected under acidic conditions. The hydrophilic PEG spacer increases solubility in aqueous media.
Synonyms	Acid-PEG8-t-butyl ester; Acid-PEG8-C2-Boc; HOOCCH2CH2O-PEG7-CH2CH2COOtBu; COOH-PEG8-OtBu; 2,2-Dimethyl-4-oxo-3,7,10,13,16,19,22,25,28-nonaoxahentriacontan-31-oic acid
IUPAC Name	3-[2-[2-[2-[2-[2-[2-[2-[3-[(2-methylpropan-2-yl)oxy]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
Canonical SMILES	CC(C)(C)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)O
InChI	InChI=1S/C24H46O12/c1-24(2,3)36-23(27)5-7-29-9-11-31-13-15-33-17-19-35-21-20-34-18-16-32-14-12-30-10-8-28-6-4-22(25)26/h4-21H2,1-3H3,(H,25,26)
InChIKey	YDPFAKTVABYUIM-UHFFFAOYSA-N
Purity	≥95%
Appearance	Pale Yellow or Colorless Oily Matter
Storage	Store at 2-8°C

COOH-PEG8-COOtBu is a polyethylene glycol (PEG) derivative with carboxyl and tert-butyl ester functional groups, extensively used in pharmaceutical and biotechnological applications. Here are some key applications of COOH-PEG8-COOtBu:

Drug Delivery Systems: COOH-PEG8-COOtBu is utilized in formulating drug delivery systems to improve the solubility and stability of therapeutics. By attaching this PEG derivative to drug molecules, pharmacokinetic properties such as circulation time and bioavailability can be enhanced. This can lead to improved therapeutic outcomes and reduced side effects.

Bioconjugation: The carboxyl group in COOH-PEG8-COOtBu allows for easy conjugation with peptides, proteins, and other biomolecules. This makes it valuable in the development of bioconjugates for diagnostic imaging and targeted therapies. The PEGylation reduces immunogenicity and increases the half-life of the conjugated molecules in biological systems.

Surface Modification: COOH-PEG8-COOtBu is employed for modifying surfaces of biomaterials and medical devices to impart anti-fouling properties. By creating a hydrophilic layer, it helps prevent protein adsorption and cell adhesion on surfaces, which is critical for applications such as blood-contacting devices and implants. This improves biocompatibility and reduces the risk of adverse immune responses.

Tissue Engineering: In tissue engineering applications, COOH-PEG8-COOtBu is used to modify scaffolds and hydrogels to enhance their mechanical properties and biological functionality. The PEG modification promotes cell adhesion and proliferation while maintaining the structural integrity of the scaffold. This facilitates the development of engineered tissues for regenerative medicine applications.

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