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CHO-Ph-CONH-PEG9-acid

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Category	CHO-Ph-CONH-PEGn-acid
Catalog NO.	BPG-0904
Product Name	CHO-Ph-CONH-PEG9-acid
Molecular Formula	C29H47NO13
Molecular Weight	617.69

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Description	CHO-Ph-CONH-PEG9-acid is a small PEG reagent with a benzaldehyde moiety and a terminal carboxylic acid group. The benzaldehyde group is reactive with hydrazide and aminooxy moiety. The terminal carboxylic acid can undergo reactions with primary amines in the presence of activators such as EDC or HATU to form a stable amide bond.
Synonyms	Ald-Ph-PEG9-acid; Ald-Ph-amido-PEG9-C2-acid; Ald-Ph-PEG9-COOH; Ald-Ph-NH-PEG9-COOH; 1-(4-Formylphenyl)-1-oxo-5,8,11,14,17,20,23,26,29-nonaoxa-2-azadotriacontan-32-oic acid
IUPAC Name	3-[2-[2-[2-[2-[2-[2-[2-[2-[2-[(4-formylbenzoyl)amino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
Canonical SMILES	O=C(O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(C1=CC=C(C=O)C=C1)=O
InChI	InChI=1S/C29H47NO13/c31-25-26-1-3-27(4-2-26)29(34)30-6-8-36-10-12-38-14-16-40-18-20-42-22-24-43-23-21-41-19-17-39-15-13-37-11-9-35-7-5-28(32)33/h1-4,25H,5-24H2,(H,30,34)(H,32,33)
InChIKey	LHXSLNQUPDXTKT-UHFFFAOYSA-N
Purity	≥95%
Storage	Store at 2-8°C

CHO-Ph-CONH-PEG9-acid is a specialized compound widely used in biochemical and medicinal research. Here are some key applications of CHO-Ph-CONH-PEG9-acid:

Drug Delivery Systems: CHO-Ph-CONH-PEG9-acid can be used in the design of advanced drug delivery systems. Its polyethylene glycol (PEG) moiety enhances the solubility and stability of therapeutic agents, improving their bioavailability. By conjugating drugs to CHO-Ph-CONH-PEG9-acid, researchers can achieve targeted delivery and controlled release, enhancing therapeutic efficacy and minimizing side effects.

Bioconjugation: CHO-Ph-CONH-PEG9-acid is instrumental in bioconjugation techniques, where it serves as a linker molecule to attach biomolecules such as antibodies or peptides to various surfaces or carriers. This facilitates the creation of functionalized surfaces for biosensors, diagnostic assays, and therapeutic agents. The PEG spacer provides flexibility and reduces steric hindrance, ensuring optimal functionality of the conjugated biomolecules.

Protein Purification: In protein chemistry, CHO-Ph-CONH-PEG9-acid is used to pegylate proteins, a process that attaches PEG chains to proteins to improve their pharmacokinetics and reduce immunogenicity. Pegylation enhances protein solubility, stability, and circulation time in the bloodstream. This is particularly useful in the development of therapeutic proteins and enzymes, such as pegylated interferons and enzymes for enzyme replacement therapies.

Chemical Synthesis: CHO-Ph-CONH-PEG9-acid is also employed in organic synthesis as an intermediate for the preparation of more complex molecules. Its functional groups allow it to participate in a variety of chemical reactions, making it a versatile building block for creating diverse compounds. Researchers utilize it to synthesize advanced materials, pharmaceuticals, and other chemical entities with specialized properties.

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