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Bromo-PEG11-alcohol

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Category Br-PEGn-OH
Catalog NO. BPG-1401
Product Name Bromo-PEG11-alcohol
CAS 1556847-51-8
Molecular Formula C22H45BrO11
Molecular Weight 565.49
Bromo-PEG11-alcohol
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Product Information

Description Bromo-PEG11-alcohol is a polyethylene glycol (PEG)-based PROTAC linker that can be used in the synthesis of a series of PROTACs.
Synonyms Br-PEG11-OH; 32-Bromo-3,6,9,12,15,18,21,24,27,30-decaoxa-1-dotriacontanol; 32-Bromo-3,6,9,12,15,18,21,24,27,30-decaoxadotriacontan-1-ol; 3,6,9,12,15,18,21,24,27,30-Decaoxadotriacontan-1-ol, 32-bromo-
IUPAC Name 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
Canonical SMILES C(COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCBr)O
InChI InChI=1S/C22H45BrO11/c23-1-3-25-5-7-27-9-11-29-13-15-31-17-19-33-21-22-34-20-18-32-16-14-30-12-10-28-8-6-26-4-2-24/h24H,1-22H2
InChIKey DFQMPBUAZLWCKJ-UHFFFAOYSA-N
Boiling Point 578.3±45.0°C (Predicted)
Purity ≥95%
Density 1.213±0.06 g/cm3 (Predicted)
Storage Store at 2-8°C
Exact Mass 564.21452
LogP 0.53960

Bromo-PEG11-alcohol, a versatile compound with widespread applications in biochemical and biotechnological domains, showcases a myriad of uses. Here are its four key applications presented with a high degree of perplexity and burstiness:

Bioconjugation: Positioned at the core of bioconjugation strategies, Bromo-PEG11-alcohol acts as a crucial link connecting various molecules ranging from proteins to peptides and antibodies. Its PEGylated structure not only enhances the solubility and stability of the conjugated biomolecules but also drives the advancement of state-of-the-art diagnostics, therapeutics, and imaging agents. This harmonious blend of components facilitates the creation of novel bioconjugates with augmented functionalities, heralding a new era of innovative biomedical applications characterized by unparalleled versatility and impact.

Drug Delivery: At the forefront of drug delivery systems, Bromo-PEG11-alcohol assumes a pivotal role in optimizing pharmaceutical compounds to elevate their pharmacokinetic properties. The integration of the PEG chain aids in mitigating immunogenic responses and prolonging the circulation time of therapeutic agents, reshaping the landscape of drug delivery mechanisms. This transformative process culminates in the development of more efficient and less cytotoxic drug delivery vehicles, marking a paradigm shift towards precision medicine and targeted therapeutic interventions that hold immense promise for medical breakthroughs and enhanced patient outcomes.

Surface Modification: Employed in the functionalization of biomaterial surfaces and nanoparticles, Bromo-PEG11-alcohol imparts invaluable hydrophilic and biocompatible properties. Its application in the preparation of medical devices and implants contributes to reducing protein adsorption and cellular adhesion, thus minimizing fouling and elevating the performance and durability of these critical tools. This intricate dance between biomaterials and biological systems underscores the crucial role of surface modification in advancing medical technology and enhancing patient care, paving the way for cutting-edge innovations in the field of biomaterials and their applications.

Polymer Chemistry: Serving as a cornerstone in the synthesis of PEGylated polymers, Bromo-PEG11-alcohol finds its niche in a myriad of fields including coatings, hydrogels, and tissue engineering scaffolds. The incorporation of PEGylation enhances the physical attributes and biocompatibility of the resulting materials, rendering them ideal for a diverse array of biomedical applications. This fusion of chemistry and biology in polymer design unlocks new avenues for creating advanced materials poised to revolutionize medical interventions and therapies, offering unparalleled potential for the future of healthcare and biotechnology.

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PEGylation of Peptides and Proteins

PEGylation of Peptides
and Proteins

Reduce the Immunogenicity of Peptide/Protein Drugs

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APPLICATIONS

APPLICATIONS

PEG linkers For Drug

Improved Circulation Half-Life

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