Br-PEG1-acid

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Category	Br-PEGn-acid
Catalog NO.	BPG-1370
Product Name	Br-PEG1-acid
CAS	1393330-33-0
Molecular Formula	C5H9BrO3
Molecular Weight	197.03

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Description	Br-PEG1-acid is a PEG linker containing a bromide group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Synonyms	Bromo-PEG1-Acid; Bromo-PEG1-propionic acid; Br-PEG1-CH2CH2COOH; Propanoic acid, 3-(2-bromoethoxy)-
IUPAC Name	3-(2-bromoethoxy)propanoic acid
Canonical SMILES	C(COCCBr)C(=O)O
InChI	InChI=1S/C5H9BrO3/c6-2-4-9-3-1-5(7)8/h1-4H2,(H,7,8)
InChIKey	REBYHCQUFPLTTH-UHFFFAOYSA-N
Boiling Point	301.7±22.0°C at 760 mmHg
Purity	≥95%
Density	1.6±0.1 g/cm3
Appearance	Pale Yellow Oily Matter
Storage	Store at 2-8°C

Br-PEG1-acid, or Bromopropyl-PEG1-acid, is a widely used reagent in various biochemical applications due to its reactive bromo group and hydrophilic PEG (polyethylene glycol) moiety. Here are some key applications of Br-PEG1-acid:

Bioconjugation: Br-PEG1-acid is commonly used in bioconjugation techniques to attach PEG to proteins, peptides, and other biomolecules. This can improve the solubility, stability, and bioavailability of therapeutic proteins. Additionally, PEGylation can reduce the immunogenicity and enhance the half-life of drugs in the bloodstream.

Drug Delivery Systems: Br-PEG1-acid can be used to develop advanced drug delivery systems by modifying nanoparticles, liposomes, or other carriers. The PEGylation process helps in creating stealth nanoparticles that evade the immune system, leading to better targeting and controlled release of drugs. This approach is particularly beneficial for delivering anticancer agents and other critical medications.

Surface Modification: Br-PEG1-acid is vital in surface modification of biomedical devices and implants. By grafting PEG onto surfaces, it helps in preventing protein adsorption and biofouling. This can enhance the biocompatibility and longevity of devices such as stents, catheters, and tissue engineering scaffolds.

Protein Labeling and Imaging: Br-PEG1-acid can be employed for protein labeling by attaching fluorescent or radioactive tags through the PEG linker. This is useful in various imaging techniques, including fluorescence microscopy and positron emission tomography (PET). Such labels enable the tracking and visualization of biological processes in real time, aiding in diagnostics and research.

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