Bis-PEG10-NHS ester

Bis-PEG10-NHS ester is a bifunctional polyethylene glycol linker with reactive NHS ester groups, which is widely used in bioconjugation and drug delivery. Here are some key applications of Bis-PEG10-NHS ester:

Protein Pegylation: Bis-PEG10-NHS ester is used in protein pegylation, a process that involves attaching polyethylene glycol chains to proteins or peptides. This process helps improve the stability, solubility, and half-life of therapeutic proteins in the bloodstream. Pegylated proteins often show reduced immunogenicity and enhanced pharmacokinetics.

Drug Conjugation: Bis-PEG10-NHS ester is utilized to link drugs to carrier molecules, such as antibodies, creating antibody-drug conjugates (ADCs). These ADCs can target specific cells, such as cancer cells, delivering the drug directly to the site of interest. This targeted approach minimizes side effects and enhances therapeutic efficacy.

Surface Modification: Bis-PEG10-NHS ester can be used to modify the surfaces of nanoparticles, beads, or other biomaterials to improve biocompatibility. By attaching PEG chains to surfaces, researchers can reduce protein adsorption and prevent non-specific binding, leading to better performance in biomedical applications. This can enhance the efficacy of diagnostic tools, biosensors, and drug delivery systems.

Crosslinking Reagents: Bis-PEG10-NHS ester can serve as a crosslinking reagent in various biological assays and experiments. It can link two different biomolecules, such as proteins, peptides, or oligonucleotides, by reacting with primary amines. This creates stable conjugates that can be used in immunoassays, enzyme-linked assays, or for creating multi-functional bioconjugates with diverse applications.