Benzyl-PEG6-alcohol

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Category	Small-molecule Heterobifunctional PEG
Catalog NO.	BPG-2044
Product Name	Benzyl-PEG6-alcohol
CAS	24342-68-5
Molecular Formula	C19H32O7
Molecular Weight	372.45

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Description	BnO-PEG6-OH is a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Synonyms	Hexaethylene Glycol Monobenzyl Ether; 1-Phenyl-2,5,8,11,14,17-hexaoxanonadecan-19-ol; 2-[2-[2-[2-[2-[2-(Benzyloxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol; 2,5,8,11,14,17-Hexaoxanonadecan-19-ol, 1-phenyl-; BzO-dPEG6-OH; BnO-PEG6-OH; 17-Phenylmethyloxy-3,6,9,12,15-pentaoxaheptadecan-1-ol
IUPAC Name	2-[2-[2-[2-[2-(2-phenylmethoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol
Canonical SMILES	C1=CC=C(C=C1)COCCOCCOCCOCCOCCOCCO
InChI	InChI=1S/C19H32O7/c20-6-7-21-8-9-22-10-11-23-12-13-24-14-15-25-16-17-26-18-19-4-2-1-3-5-19/h1-5,20H,6-18H2
InChIKey	VVBQKDDPSXBMMZ-UHFFFAOYSA-N
Boiling Point	473.6±40.0 °C at 760 mmHg
Flash Point	240.3±27.3 °C
Purity	≥95%
Density	1.097±0.06 g/cm3 (Predicted)
Solubility	Soluble in DCM, DMF, DMSO
Related CAS	26403-74-7 (polymer) 1201808-31-2 (polymer)
Appearance	Colorless to light yellow clear liquid
Shelf Life	0-4°C for short term (days to weeks), or -20°C for long term (months).
Storage	Store at 2-8°C
Vapor Pressure	0.0±1.2 mmHg at 25°C
LogP	-0.54

Benzyl-PEG6-alcohol, a versatile compound utilized in chemical biology and pharmaceutical development, presents a myriad of key applications with high perplexity and burstiness:

Polymer Conjugation: Embracing Benzyl-PEG6-alcohol for PEGylation of biomolecules enhances solubility and stability, revolutionizing drug delivery systems. By conjugating PEG chains to therapeutic agents, pharmacokinetic properties are optimized, extending half-life and mitigating immunogenicity. This strategy is pivotal for creating cutting-edge drug delivery platforms with enhanced efficacy.

Chemical Synthesis: In the realm of organic synthesis, Benzyl-PEG6-alcohol emerges as a crucial intermediate, boasting functional groups that facilitate intricate chemical adaptations. Its utility in constructing complex molecules simplifies the synthesis of pharmaceuticals and specialty chemicals, ushering in innovative pathways for synthetic design.

Surface Coating: Employing Benzyl-PEG6-alcohol in surface modification endeavors transforms medical devices and biosensors with biocompatible, non-fouling surfaces. By coating substrates with PEGylated layers, protein adsorption and cellular adherence are thwarted, enhancing implant performance and durability. This application plays a pivotal role in advancing biomedical device technology.

Drug Delivery Systems: Benzyl-PEG6-alcohol stands at the forefront of formulating drug conjugates and nanoparticles for precise drug delivery, with its PEG moiety offering a hydrophilic surface that prolongs circulation time and diminishes clearance rates of drug carriers. This enables targeted delivery to specific tissues or cells, elevating therapeutic efficacy while minimizing adverse effects.

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