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Benzyl-PEG2-acid

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Category	Small-molecule Heterobifunctional PEG
Catalog NO.	BPG-1785
Product Name	Benzyl-PEG2-acid
CAS	91555-65-6
Molecular Formula	C12H16O4
Molecular Weight	224.25

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Description	Benzyl-PEG2-acid is a PEG linker containing a benzyl protecting group and a carboxylic acid group. Benzyl is an alcohol protecting group and can be removed via hydrogenolysis. The carboxylic acid group can react with primary amine groups in the presence of activators such as EDC or HATU to form a stable amide bond.
Synonyms	6-Benzyloxy-4-oxahexanoic acid; Propanoic acid, 3-[2-(phenylmethoxy)ethoxy]-; 3-(2-(Benzyloxy)ethoxy)propanoic acid
IUPAC Name	3-(2-phenylmethoxyethoxy)propanoic acid
Canonical SMILES	C1=CC=C(C=C1)COCCOCCC(=O)O
InChI	InChI=1S/C12H16O4/c13-12(14)6-7-15-8-9-16-10-11-4-2-1-3-5-11/h1-5H,6-10H2,(H,13,14)
InChIKey	SUIUDJXITUDGOR-UHFFFAOYSA-N
Boiling Point	364.0±27.0°C at 760 mmHg
Purity	≥95%
Density	1.1±0.1 g/cm3
Appearance	Pale Yellow Oily Liquid
Storage	Store at 2-8°C
Exact Mass	224.10485899

Benzyl-PEG2-acid, a versatile molecule widely utilized in biotechnological and pharmaceutical domains, serves various purposes. Here are four key applications of Benzyl-PEG2-acid portrayed with a high degree of perplexity and burstiness:

Drug Delivery Systems: Incorporating Benzyl-PEG2-acid into drug delivery system design aims to elevate the solubility and stability of therapeutic compounds. By conjugating drugs with PEG moieties, these systems extend the circulation time of medications in the bloodstream and mitigate immunogenic responses. This approach not only enhances the efficacy and safety profiles of a diverse range of drugs, but also broadens the horizons of therapeutic applications.

Protein Conjugation: Within the realms of protein engineering and bioconjugation, Benzyl-PEG2-acid plays a crucial role in modifying proteins to enhance their therapeutic potential. PEGylation of proteins utilizing this compound can reduce immunogenic reactions and enhance stability, fostering the development of more potent biologics with minimized side effects. This application serves as a cornerstone in the production of enduring therapeutic proteins and enzymes with heightened efficacy.

Surface Modification: Harnessing Benzyl-PEG2-acid, researchers can customize the surfaces of biomaterials and medical devices to optimize their functionality. Coating surfaces with PEG helps prevent protein adsorption and cell adhesion, reducing non-specific binding and promoting enhanced biocompatibility. This surface modification technique is indispensable for advancing implantable devices and diagnostic tools.

Nanoparticle Functionalization: In the realm of nanomedicine, Benzyl-PEG2-acid emerges as a critical component for nanoparticle functionalization, particularly in targeted drug delivery and imaging applications. PEGylated nanoparticles incorporating this compound display improved pharmacokinetics and reduced aggregation in biological settings. This tailored approach enables precise delivery of therapeutic agents to specific disease sites, enhancing treatment effectiveness and minimizing adverse effects.

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