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Amino-PEG8-amine

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Category Small-molecule Homobifunctional PEG
Catalog NO. BPG-2109
Product Name Amino-PEG8-amine
CAS 82209-36-7
Molecular Formula C₁₈H₄₀N₂O₈
Molecular Weight 412.52
Amino-PEG8-amine
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Product Information

Description Amino-PEG8-amine is a polyethylene glycol (PEG)-based PROTAC linker. Amino-PEG8-amine can be used in the synthesis of a series of PROTACs.
Synonyms H2N-PEG8-CH2CH2NH2; 1,26-Diamino-3,6,9,12,15,18,21,24-octaoxahexacosane
IUPAC Name 2-[2-[2-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanamine
Canonical SMILES C(COCCOCCOCCOCCOCCOCCOCCOCCN)N
InChI InChI=1S/C18H40N2O8/c19-1-3-21-5-7-23-9-11-25-13-15-27-17-18-28-16-14-26-12-10-24-8-6-22-4-2-20/h1-20H2
InChIKey QNNWDQWXZAXENQ-UHFFFAOYSA-N
Boiling Point 493.4±40.0 °C at 760 mmHg
Purity >97%
Density 1.1±0.1 g/cm3
Appearance Colorless Liquid
Storage Please store the product under the recommended conditions in the Certificate of Analysis.

Amino-PEG8-amine, a versatile polyethylene glycol derivative extensively utilized in biochemical and pharmaceutical realms, boasts a myriad of applications. Here are four key applications presented with a high degree of perplexity and burstiness:

Drug Delivery Systems: In the realm of drug delivery systems, Amino-PEG8-amine plays a pivotal role in enhancing the solubility and stability of therapeutic agents. By coupling this compound with drugs, researchers can augment their bioavailability and regulate their release within the body. This results in the creation of more potent and precisely targeted treatment modalities for a spectrum of diseases.

Bioconjugation: Within the domain of bioconjugation, Amino-PEG8-amine serves as a crucial linker molecule, facilitating the conjugation of proteins, peptides, or other biomolecules onto surfaces or other molecular entities. Its flexible polyether backbone offers optimal spacing, diminishing steric hindrances between conjugated entities. This feature is indispensable for the development of diagnostic assays, biosensors, and targeted therapeutic interventions, heralding a new era of precision medicine.

Surface Functionalization: Amino-PEG8-amine finds application in the modification and functionalization of surfaces in biomedical devices and materials science. For instance, it can be employed to coat nanoparticles, ameliorating their biocompatibility and mitigating nonspecific interactions with biological systems. This enhancement elevates the performance and durability of implants, sensors, and other medical devices, ushering in advancements in healthcare technology.

Protein Stabilization: Playing a crucial role in protein stabilization, Amino-PEG8-amine safeguards against aggregation and denaturation. Through the conjugation of this molecule to proteins, researchers can uphold their structural integrity and functionality across diverse conditions. This application holds significant importance in the formulation of therapeutic proteins, ensuring their efficacy and stability throughout storage and administration processes, underscoring the importance of precision in pharmaceutical development and delivery.

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