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Amino-PEG6-alcohol

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Category Small-molecule Heterobifunctional PEG
Catalog NO. BPG-1886
Product Name Amino-PEG6-alcohol
CAS 39160-70-8
Molecular Formula C12H27NO6
Molecular Weight 281.35
Amino-PEG6-alcohol
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Product Information

Description Amino-PEG6-OH is a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Synonyms 17-Amino-3,6,9,12,15-pentaoxaheptadecan-1-ol; H2N-PEG6-OH; 1-Aminohexaethylene Glycol
IUPAC Name 2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol
Canonical SMILES C(COCCOCCOCCOCCOCCO)N
InChI InChI=1S/C12H27NO6/c13-1-3-15-5-7-17-9-11-19-12-10-18-8-6-16-4-2-14/h14H,1-13H2
InChIKey ICUIZKMGHRMMDZ-UHFFFAOYSA-N
Boiling Point 388.0±37.0 °C at 760 mmHg
Flash Point 188.5±26.5 °C
Purity ≥95%
Density 1.1±0.1 g/cm3
Solubility Soluble in DMSO (10 mm)
Related CAS 933789-97-0 (polymer)
Appearance Pale Yellow or Colorless Oily Matter
Storage Store at 2-8°C
Exact Mass 281.18383758
Vapor Pressure 0.0±2.0 mmHg at 25°C
LogP -2.80
Pictogram(s) Irritant
Signal Warning
Precautionary Statement Codes P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Amino-PEG6-alcohol, a polyethylene glycol derivative, has numerous applications in the fields of biotechnology and pharmaceuticals. Here are some key applications of Amino-PEG6-alcohol:

Drug Delivery Systems: Amino-PEG6-alcohol is often used to improve the solubility and stability of pharmaceutical compounds. By conjugating drugs with PEG, the circulation time in the bloodstream is increased, enhancing the bioavailability and therapeutic efficacy. This can lead to more effective treatments with reduced dosing frequency.

Protein Modification: In biotechnology, Amino-PEG6-alcohol is used to modify proteins and peptides to improve their pharmacokinetic properties. The PEGylation process can reduce immunogenicity and increase the half-life of therapeutic proteins. This modification is crucial for the development of biologics and peptide-based drugs.

Diagnostics: Amino-PEG6-alcohol finds application in the development of diagnostic assays and imaging agents. By attaching PEG chains to antibodies or other biomolecules, the stability and functionality of diagnostic reagents can be enhanced. This results in more accurate and reliable diagnostic tests and imaging techniques.

Bioconjugation: Amino-PEG6-alcohol is extensively used in bioconjugation techniques for attaching various biomolecules, such as enzymes, antibodies, and nucleic acids. The PEG linker provides flexibility and reduces steric hindrance, facilitating the formation of stable conjugates. This is essential for creating multifunctional bioconjugates for research and therapeutic applications.

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PEGylation of Peptides and Proteins

PEGylation of Peptides
and Proteins

Reduce the Immunogenicity of Peptide/Protein Drugs

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PEG linkers For Drug

Improved Circulation Half-Life

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