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Amino-PEG4-propionic acid

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Category Small-molecule Heterobifunctional PEG
Catalog NO. BPG-1855
Product Name Amino-PEG4-propionic acid
CAS 663921-15-1
Molecular Formula C11H23NO6
Molecular Weight 265.30
Amino-PEG4-propionic acid
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Product Information

Description NH2-PEG4-CH2CH2COOH is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Synonyms 1-Amino-3,6,9,12-tetraoxapentadecan-15-oic acid; Amino-PEG4-acid; (PEO)4-amino-propionic acid
IUPAC Name 3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]propanoic acid
Canonical SMILES C(COCCOCCOCCOCCN)C(=O)O
InChI InChI=1S/C11H23NO6/c12-2-4-16-6-8-18-10-9-17-7-5-15-3-1-11(13)14/h1-10,12H2,(H,13,14)
InChIKey DKUZHSDZSMQOGQ-UHFFFAOYSA-N
Boiling Point 409.6±40.0 °C at 760 mmHg
Flash Point 201.5±27.3 °C
Purity > 98.0 %
Density 1.1±0.1 g/cm3
Solubility 10 mm in DMSO
Related CAS 1818294-41-5 (polymer) 196936-04-6 (polymer)
Appearance Solid
Storage -20 °C
Exact Mass 265.15253745
Vapor Pressure 0.0±2.1 mmHg at 25°C
LogP -1.92
Pictogram(s) Irritant
Signal Warning
Precautionary Statement Codes P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Amino-PEG4-propionic acid, a versatile compound with wide-ranging applications in biochemical and biotechnological fields, plays a pivotal role in various processes. Here are four key applications presented with high perplexity and burstiness:

Bioconjugation: Amino-PEG4-propionic acid serves as a cornerstone in bioconjugation strategies, enabling the linkage of biomolecules such as proteins, antibodies, and peptides via its functional amino group. This fosters the creation of durable bioconjugates essential for diagnostics, therapeutics, and biosensors. The inclusion of a PEG spacer enhances molecular solubility and stability while mitigating steric hindrance, elevating the quality of the resulting conjugates.

Drug Delivery Systems: Through PEGylation with Amino-PEG4-propionic acid, drugs undergo a transformation in their pharmacokinetic properties, bolstering solubility, diminishing immunogenicity, and extending circulation time within the bloodstream. This compound also finds utility in modifying drug delivery carriers like liposomes and nanoparticles, enhancing their biocompatibility and targeting precision for optimized drug delivery efficiency.

Surface Modification: The application of Amino-PEG4-propionic acid in surface modifications of diverse biomaterials for biomedical purposes yields substantial benefits. Integration onto surfaces such as implants and medical devices curbs unwanted protein adsorption and diminishes immune reactions, enhancing the biocompatibility and operational efficacy of medical devices, ultimately leading to improved patient outcomes.

Protein Purification: Leveraging the amino group within Amino-PEG4-propionic acid, researchers can establish affinity tags crucial for protein purification endeavors. By attaching this compound to proteins of interest, the capture and isolation of target proteins from intricate mixtures are expedited, ensuring the production of high-purity proteins vital for both research and therapeutic applications.

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PEGylation of Peptides and Proteins

PEGylation of Peptides
and Proteins

Reduce the Immunogenicity of Peptide/Protein Drugs

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