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Amino-PEG3-alcohol

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Category Small-molecule Heterobifunctional PEG
Catalog NO. BPG-1709
Product Name Amino-PEG3-alcohol
CAS 6338-55-2
Molecular Formula C6H15NO3
Molecular Weight 149.19
Amino-PEG3-alcohol
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Product Information

Description 2-[2-(2-Aminoethoxy)ethoxy]ethanol (CAS# 6338-55-2) is a useful research chemical compound.
Synonyms 2-[2-(2-aminoethoxy)ethoxy]ethanol; 2-[2-(2-aminoethoxy)ethoxy]ethanol
IUPAC Name 2-[2-(2-aminoethoxy)ethoxy]ethanol
Canonical SMILES C(COCCOCCO)N
InChI InChI=1S/C6H15NO3/c7-1-3-9-5-6-10-4-2-8/h8H,1-7H2
InChIKey ASDQMECUMYIVBG-UHFFFAOYSA-N
Boiling Point 253.8 °C at 760 mmHg
Purity >98%
Density 1.054 g/cm3
Solubility In DMSO: 100 mg/mL (670.29 mM; Need ultrasonic)
Related CAS 933789-97-0 (polymer)
Appearance Colorless Liquid
Storage 4°C, protect from light; In solvent, -80°C, 6 months; -20°C, 1 month (protect from light)
Exact Mass 149.10519334
LogP -0.32910
Pictogram(s) Corrosive
Signal Danger
Precautionary Statement Codes P260, P264, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P363, P405, and P501

Amino-PEG3-alcohol, a versatile linker molecule, finds diverse applications in bioconjugation and drug delivery systems. Here are four key applications presented with high perplexity and burstiness:

Drug Conjugation: Utilizing Amino-PEG3-alcohol, researchers attach drugs to carrier molecules, like antibodies or nanoparticles, enhancing solubility and stability. This coupling ensures targeted drug delivery to specific cells, decreasing off-target effects and enhancing therapeutic efficacy. Furthermore, conjugation with Amino-PEG3-alcohol can extend the half-life of therapeutics in circulation, optimizing treatment outcomes.

Targeted Drug Delivery: The versatility of Amino-PEG3-alcohol in linking biologically active compounds to targeting moieties, such as ligands or antibodies, is pivotal in crafting precise drug delivery systems. This targeted approach directs therapeutic agents specifically to afflicted areas like tumors or inflamed tissues, maximizing treatment effectiveness while minimizing adverse effects.

Surface Modification: Amino-PEG3-alcohol serves a crucial role in modifying the surfaces of diverse biomaterials, including nanoparticles, medical devices, and biosensors. By binding to these surfaces, it enhances biocompatibility, diminishes protein adsorption, and decreases immune recognition. Such surface modification is indispensable for advancing biomedical devices and diagnostic instruments.

Bioconjugation Research: In laboratory investigations, Amino-PEG3-alcohol emerges as a key reagent for conjugating biomolecules, such as proteins, peptides, and nucleic acids. This enables the creation of multifunctional complexes employed in various assays, like immunoassays and molecular diagnostics. Through such conjugation processes, researchers gain deeper insights into protein interactions and cellular pathways, enriching our understanding of biological mechanisms.

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PEGylation of Peptides and Proteins

PEGylation of Peptides
and Proteins

Reduce the Immunogenicity of Peptide/Protein Drugs

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