Allyl-PEG4-OH

Name: Allyl-PEG4-OH
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Category	Allyl-PEGn-OH
Catalog NO.	BPG-0098
Product Name	Allyl-PEG4-OH
CAS	26150-06-1
Molecular Formula	C11H22O5
Molecular Weight	234.29

Allyl-PEG4-OH @(data.CAS != null ? $"| CAS 26150-06-1" : "") - BOC Sciences

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Description	Allyl-PEG4-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
Synonyms	3,6,9,12-Tetraoxapentadec-14-en-1-ol; Acryloyl-PEG4-OH; 11-Allyloxy-3,6,9-trioxaundecanol; 3,6,9,12-Tetraoxa-14-pentadecene-1-ol; 4,7,10,13-Tetraoxa-1-pentadecen-15-ol; 2-{2-[2-(2-Allyloxyethoxy)ethoxy]ethoxy}ethanol; Tetraethylene glycol allyl ether
IUPAC Name	2-[2-[2-(2-prop-2-enoxyethoxy)ethoxy]ethoxy]ethanol
SMILES	C=CCOCCOCCOCCOCCO
InChI	InChI=1S/C11H22O5/c1-2-4-13-6-8-15-10-11-16-9-7-14-5-3-12/h2,12H,1,3-11H2
InChIKey	UFTWTGQGRPPFKF-UHFFFAOYSA-N
Boiling Point	315.3±32.0°C at 760 mmHg
Purity	≥95%
Density	1.0±0.1 g/cm3
Storage	Store at 2-8°C

Allyl-PEG4-OH, a versatile polyethylene glycol derivative, finds extensive use in bioconjugation and drug delivery applications. Here are four key applications of Allyl-PEG4-OH presented with high perplexity and burstiness:

Bioconjugation: Frequently employed in the modification of proteins, peptides, and other biomolecules, Allyl-PEG4-OH plays a pivotal role in enhancing their solubility, stability, and biocompatibility. By conjugating Allyl-PEG4-OH to therapeutic proteins, researchers can refine their pharmacokinetics and mitigate immunogenic responses. This modification is indispensable for crafting long-circulating drugs and precision-targeted delivery systems, revolutionizing the field of bioconjugation.

Drug Delivery: Acting as a vital link between therapeutic agents and targeting ligands or nanoparticles, Allyl-PEG4-OH facilitates the solubility and bioavailability of hydrophobic drugs in advanced drug delivery systems. This property is essential for formulating highly effective drug delivery platforms capable of achieving precise target delivery and controlled release of therapeutics, ushering in a new era of targeted drug delivery strategies.

Surface Functionalization: In the realm of drug carriers and nanoparticles, Allyl-PEG4-OH is utilized to functionalize their surfaces, imparting hydrophilic and biocompatible properties. This enhancement reduces non-specific binding and extends the circulation time of nanoparticles within the bloodstream, particularly advantageous in the development of stealth nanoparticles for cutting-edge drug delivery and imaging applications, showcasing the importance of surface functionalization in biomedical research.

Chemical Synthesis: Serving as a versatile building block in organic synthesis, Allyl-PEG4-OH plays a crucial role in creating PEGylated compounds with enhanced solubility and processing characteristics. This reagent enables the introduction of PEGylation into various chemical structures, improving their properties and offering flexibility while reducing steric hindrance. The PEG4 spacer's unique attributes make it invaluable in designing complex molecules and conjugates, driving innovation in chemical synthesis methodologies.

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