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AcS-PEG2-t-butyl ester

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Category AcS-PEGn-t-butyl ester
Catalog NO. BPG-0087
Product Name AcS-PEG2-t-butyl ester
CAS 1820641-93-7
Molecular Formula C13H24O5S
Molecular Weight 292.39
AcS-PEG2-t-butyl ester
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Product Information

Description AcS-PEG2-t-butyl ester is a PEG linker containing a sulfur acetyl group and a t-butyl ester. The sulfur acetyl group can be deprotected to form a thiol group. The t-butyl ester can be removed under acidic conditions. The hydrophilic PEG linker increases the water solubility of compounds in aqueous media.
Synonyms S-acetyl-PEG2-t-butyl ester; 1,1-Dimethylethyl 3-[2-[2-(acetylthio)ethoxy]ethoxy]propanoate; S-acetyl-PEG2-Boc; Propanoic acid, 3-[2-[2-(acetylthio)ethoxy]ethoxy]-, 1,1-dimethylethyl ester; 2-Methyl-2-propanyl 3-{2-[2-(acetylsulfanyl)ethoxy]ethoxy}propanoate
IUPAC Name tert-butyl 3-[2-(2-acetylsulfanylethoxy)ethoxy]propanoate
Canonical SMILES CC(=O)SCCOCCOCCC(=O)OC(C)(C)C
InChI InChI=1S/C13H24O5S/c1-11(14)19-10-9-17-8-7-16-6-5-12(15)18-13(2,3)4/h5-10H2,1-4H3
InChIKey DSBKYHJZFUGMFX-UHFFFAOYSA-N
Boiling Point 373.4±27.0°C at 760 mmHg
Purity ≥95%
Density 1.1±0.1 g/cm3
Solubility Soluble in DMSO
Appearance Pale Yellow Oily Matter
Storage Store at 2-8°C

AcS-PEG2-t-butyl ester, a marvel of chemical complexity with multifaceted roles in bioconjugation and drug delivery, reigns supreme in the realm of molecular intricacies and sentence fluidity.

Bioconjugation: Positioned at the enigmatic intersection of chemistry and biology, AcS-PEG2-t-butyl ester emerges as the catalyst of choice for bioconjugation of proteins and peptides. By skillfully grafting the PEG moiety onto biomolecules, it enhances their solubility and stability, a technique often utilized in crafting antibody-drug conjugates that seamlessly combine the precision of antibodies with the therapeutic potency of drugs.

Drug Delivery: Amplifying its significance within the domain of drug delivery systems, AcS-PEG2-t-butyl ester plays a pivotal role in linking therapeutic agents to carriers like nanoparticles. The art of PEGylation extends circulation time and reduces immunogenicity, thereby enhancing drug efficacy and ushering in treatments that wield greater potency while minimizing side effects.

Surface Functionalization: In the intricate realm of medical devices and diagnostic instruments, this compound finds its niche in surface functionalization. By embellishing surfaces with PEG, it mitigates nonspecific binding and enhances biocompatibility, a critical step towards elevating the efficiency of biosensors and implants, thereby setting new benchmarks for performance standards.

Polymer Chemistry: Nestled within the vibrant tapestry of polymer chemistry, AcS-PEG2-t-butyl ester stands as a cornerstone for sculpting pegylated polymers. These polymers serve diverse purposes, including the creation of hydrogels crucial for controlled drug release and tissue engineering. The versatility of pegylated polymers unveils pathways to a myriad of biotechnological applications, underscoring their indispensable role in contemporary scientific endeavors.

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PEGylation of Peptides and Proteins

PEGylation of Peptides
and Proteins

Reduce the Immunogenicity of Peptide/Protein Drugs

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