-20°C for long-term preservation, keep in dry and avoid sunlight. Avoid repeated freezing and thawing.
Soluble in water and most organic solvents, freshly prepared before use.
mPEG-ALD (methoxy-polyethylene glycol-propionaldehyde) is a linear, monofunctional modified PEG terminated with a methoxy group at one end and an aldehyde group at the other end. The aldehyde group can react with the N-terminus of the peptide and protein to form a C=N double bond, which can be further used for this reaction. The mPEG-ALD or ketone derivative can also undergo a reversible reaction with hydrazine to form a hydrazide bond.
1. An, Se Yong, et al. Preparation of monodisperse and size-controlled poly (ethylene glycol) hydrogel nanoparticles using liposome templates. Journal of colloid and interface science, 2009, 331(1): 98-103. 2. Groll, J., et al. Comparison of Coatings from Reactive Star Shaped PEG-s tat-PPG Prepolymers and Grafted Linear PEG for Biological and Medical Applications. Biomacromolecules, 2005, 6(2): 956-962.