-20°C for long-term preservation, keep in dry and avoid sunlight. Avoid repeated freezing and thawing.
Soluble in water, DMSO and DMF. Freshly prepared before use.
SC-PEG-SC has two identical activated terminal groups. SC is a very reactive NHS ester. The urethane bond formed by its coupling with the protein is more stable than the ester bond. Homobifunctionalized PEG derivatives have wide applications in peptides, proteins, lipids, other small molecules and surface modifications. Drug PEGylation can alter its dispersity and solubility in aqueous solutions. PEG modification can create a spatial barrier around the drug, reduce the enzymatic hydrolysis of the drug, avoid the rapid elimination of kidney metabolism, and allow the drug to be recognized by cells of the immune system.
1. Kozlowski, Antoni, and J. Milton Harris. Improvements in protein PEGylation: pegylated interferons for treatment of hepatitis C. Journal of Controlled Release, 2001, 72(1-3): 217-224. 2. Chung, Eunna, et al. Evaluation of gold nanotracers to track adipose-derived stem cells in a PEGylated fibrin gel for dermal tissue engineering applications. International journal of nanomedicine, 2013, 8: 325.