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Triethylene glycol monomethyl ether

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Category Small-molecule Methoxy Linear PEG (mPEG)
Catalog NO. BPG-1715
Product Name Triethylene glycol monomethyl ether
CAS 112-35-6
Molecular Formula C7H16O4
Molecular Weight 164.20
Triethylene glycol monomethyl ether
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Product Information

Description Triethylene glycol monomethyl ether (CAS# 112-35-6) is a polymer which has been used in the synthesis of glycidyl triazolyl polymers.
Synonyms 2-[2-(2-methoxyethoxy)ethoxy]ethanol
IUPAC Name 2-[2-(2-methoxyethoxy)ethoxy]ethanol
Canonical SMILES COCCOCCOCCO
InChI InChI=1S/C7H16O4/c1-9-4-5-11-7-6-10-3-2-8/h8H,2-7H2,1H3
InChIKey JLGLQAWTXXGVEM-UHFFFAOYSA-N
Boiling Point 122 °C (10 mmHg)
Melting Point -44°C
Flash Point 118°C
Purity purum, ≥97.0% (GC)
Density 1.026 g/cm3
Solubility 6.09 M;In water, miscible;Soluble in water;Solubility in heptane = 1.5 wt%, completely soluble in acetone, benzene, ethyl ether, methanol, and carbon tetrachloride at 25 °C.;Solubility in water: miscible
Appearance Viscous colorless liquid
Application Activated PEG derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. PEGylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of PEG improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. In addition to PEGylation, activated PEG derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity.
Storage Inert atmosphere, Room Temperature
Exact Mass 164.10485899
Vapor Pressure 0.0035 [mmHg]
LogP -1.46 (calculated)
Decomposition When heated to decomposition it emits acrid smoke and irritating fumes.
Refractive Index 1.4381 at 21 °C
Pictogram(s) Irritant
Signal Warning
Precautionary Statement Codes P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, and P362+P364

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PEGylation of Peptides and Proteins

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