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Tos-PEG3-THP

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Category	Tos-PEGn-THP
Catalog NO.	BPG-3471
Product Name	Tos-PEG3-THP
CAS	69502-33-6
Molecular Formula	C18H28O7S
Molecular Weight	388.48

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Description	Tos-PEG3-THP is a PEG linker with a tosyl moiety and THP protecting group. It is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media. THP is an alcohol protection group that can be removed under acidic conditions. Tosyl is an excellent leaving group for nucleophilic substitution reaction.
Synonyms	Toluene-4-sulfonic acid 2-(2-[2-(tetrahydro-pyran-2-yloxy)-ethoxy]-ethoxy)-ethyl ester; 2-(2-(2-((ethyl(tosyl)-γ3-oxidaneyl)oxy)ethoxy)ethoxy)tetrahydro-2H-pyran
IUPAC Name	2-[2-[2-(oxan-2-yloxy)ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate
Canonical SMILES	CC1=CC=C(C=C1)S(=O)(=O)OCCOCCOCCOC2CCCCO2
InChI	InChI=1S/C18H28O7S/c1-16-5-7-17(8-6-16)26(19,20)25-15-13-22-11-10-21-12-14-24-18-4-2-3-9-23-18/h5-8,18H,2-4,9-15H2,1H3
InChIKey	IUELZZOCOJFXRF-UHFFFAOYSA-N
Boiling Point	522.3±50.0 °C at 760 mmHg
Purity	≥95%
Density	1.2±0.1 g/cm3
Storage	Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)

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