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SPDP-Val-Cit-PAB-PNP

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Category	SPDP Peptide
Catalog NO.	BPG-4435
Product Name	SPDP-Val-Cit-PAB-PNP
Molecular Formula	C33H39N7O9S2
Molecular Weight	741.8

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Description	SPDP-Val-Cit-PAB-PNP is a cleavable ADC linker featuring an SPDP group, a Val-Cit dipeptide, a para-aminobenzyl (PAB) spacer and a para-nitrophenyl (PNP) carbonate group. SPDP is a thiol-specific covalent linker which forms disulfide bonds with cysteine residues of proteins. Val-Cit-PAB is a protease-cleavable linker which is designed for efficient payload release upon proteolysis. Finally, PNP is a good leaving group which is activated towards nucleophilic attack such as from amines.
Synonyms	OPSS-Val-Cit-PAB-PNP; SPDP-Val-Cit-PAB-PNP; AKOS040743747; BP-24353; HY-141145; CS-0115828; [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-3-methyl-2-[3-(pyridin-2-yldisulfanyl)propanoylamino]butanoyl]amino]pentanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate
IUPAC Name	[4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-3-methyl-2-[3-(pyridin-2-yldisulfanyl)propanoylamino]butanoyl]amino]pentanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate
Canonical SMILES	CC(C)C(C(=O)NC(CCCNC(=O)N)C(=O)NC1=CC=C(C=C1)COC(=O)OC2=CC=C(C=C2)[N+](=O)[O-])NC(=O)CCSSC3=CC=CC=N3
InChI	InChI=1S/C33H39N7O9S2/c1-21(2)29(39-27(41)16-19-50-51-28-7-3-4-17-35-28)31(43)38-26(6-5-18-36-32(34)44)30(42)37-23-10-8-22(9-11-23)20-48-33(45)49-25-14-12-24(13-15-25)40(46)47/h3-4,7-15,17,21,26,29H,5-6,16,18-20H2,1-2H3,(H,37,42)(H,38,43)(H,39,41)(H3,34,36,44)/t26-,29-/m0/s1
InChIKey	QXQFQQZJUFCHCZ-WNJJXGMVSA-N
Purity	0.98
Storage	-20°C

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