SPDP-PEG3-NHS ester
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| Category | SPDP-PEGn-NHS ester |
| Catalog NO. | BPG-3502 |
| Product Name | SPDP-PEG3-NHS ester |
| CAS | 1433996-79-2 |
| Molecular Formula | C21H29N3O8S2 |
| Molecular Weight | 515.6 |
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| Description | SPDP-PEG3-NHS ester is a PEG-based PROTAC linker that has an amine-reactive N-hydroxysuccinimide (NHS) ester at one end and a sulfhydryl-reactive 2-pyridyldithiol group at the opposite end. This has a single molecular weight PEG spacer arm, which confers greater water solubility to the crosslinker and linked proteins compared to crosslinkers having only hydrocarbon spacers. |
| Synonyms | SPDP-dpeg(R)3-NHS ester; Opss-peg(3)-nhs; 2,5-dioxopyrrolidin-1-yl 2-(2-ethoxyethoxy)-3-(2-(3-(pyridin-2-yldisulfaneyl)propanamido)ethoxy)propanoate |
| IUPAC Name | (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[3-(pyridin-2-yldisulfanyl)propanoylamino]ethoxy]ethoxy]ethoxy]propanoate |
| Canonical SMILES | C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCNC(=O)CCSSC2=CC=CC=N2 |
| InChI | InChI=1S/C21H29N3O8S2/c25-17(7-16-33-34-18-3-1-2-8-23-18)22-9-11-30-13-15-31-14-12-29-10-6-21(28)32-24-19(26)4-5-20(24)27/h1-3,8H,4-7,9-16H2,(H,22,25) |
| InChIKey | RAWBJJSJJQXTMI-UHFFFAOYSA-N |
| Purity | ≥95% |
| Appearance | Colorless Oily Matter |
| Storage | Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years) |
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Technical Information
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Industry News
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- Polyethylene Glycol (PEG) Modified Targeting Nanomaterials
- Preparation Method of PEG Hydrogel
- The PROTAC Technology in Drug Development
- What are Biotinylation and Biotinylated PEG?
- What are Lipid Excipients and Their Applications?
- What are Lipid Nanoparticles and Their Applications?
- What are Lipid-Drug Conjugates (LDCs)?
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