SPDP-PEG2-NHS ester
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| Category | SPDP-PEGn-NHS ester |
| Catalog NO. | BPG-3507 |
| Product Name | SPDP-PEG2-NHS ester |
| CAS | 2517392-28-6 |
| Molecular Formula | C19H25N3O7S2 |
| Molecular Weight | 471.54 |
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| Description | SPDP-PEG2-NHS ester is a PEG-based PROTAC linker that has an amine-reactive N-hydroxysuccinimide (NHS) ester at one end and a sulfhydryl-reactive 2-pyridyldithiol group at the opposite end. This has a single molecular weight PEG spacer arm, which confers greater water solubility to the crosslinker and linked proteins compared to crosslinkers having only hydrocarbon spacers. |
| Synonyms | SPDP-dpeg(R)2-NHS ester; Opss-peg(2)-nhs; 2,5-dioxopyrrolidin-1-yl 2-ethoxy-3-(2-(3-(pyridin-2-yldisulfaneyl)propanamido)ethoxy)propanoate |
| IUPAC Name | (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[3-(pyridin-2-yldisulfanyl)propanoylamino]ethoxy]ethoxy]propanoate |
| Canonical SMILES | O=C(ON1C(CCC1=O)=O)CCOCCOCCNC(CCSSC2=NC=CC=C2)=O |
| InChI | InChI=1S/C19H25N3O7S2/c23-15(7-14-30-31-16-3-1-2-8-21-16)20-9-11-28-13-12-27-10-6-19(26)29-22-17(24)4-5-18(22)25/h1-3,8H,4-7,9-14H2,(H,20,23) |
| InChIKey | LDTGPHMYBSIGQK-UHFFFAOYSA-N |
| Purity | ≥95% |
| Appearance | Colorless Oily Matter |
| Storage | Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years) |
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Technical Information
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Industry News
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- The PROTAC Technology in Drug Development
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