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SPDP-PEG1-COOH

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Category SPDP-PEGn-COOH
Catalog NO. BPG-3492
Product Name SPDP-PEG1-COOH
Molecular Formula C13H18N2O4S2
Molecular Weight 330.42
SPDP-PEG1-COOH
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Product Information

Description SPDP-PEG1-COOH is a PEG-based PROTAC linker which is applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. It contains SPDP crosslinker and carboxylic acid moieties. SPDP is reactive toward amine and thiol groups and contains a cleavable disulfide bond. Its membrane permeability allows for intracellular crosslinking reactions. The terminal caboxylic acid can react with primary amines in the presence of activators such as EDC and DCC to form stable amide bonds. The water solubility properties of PEG linkers is enhanced by longer PEG chains.
Synonyms SPDP-PEG1-acid; OPSS-PEG1-COOH; 3-(2-(3-(pyridin-2-yldisulfaneyl)propanamido)ethoxy)propanoic acid
IUPAC Name 3-[2-[3-(pyridin-2-yldisulfanyl)propanoylamino]ethoxy]propanoic acid
Canonical SMILES O=C(O)CCOCCNC(CCSSC1=NC=CC=C1)=O
InChI InChI=1S/C13H18N2O4S2/c16-11(14-7-9-19-8-4-13(17)18)5-10-20-21-12-3-1-2-6-15-12/h1-3,6H,4-5,7-10H2,(H,14,16)(H,17,18)
InChIKey AYNPWJSUSQCCTQ-UHFFFAOYSA-N
Purity ≥95%
Appearance Light Yellow or White Solid
Storage Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)

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PEGylation of Peptides and Proteins

PEGylation of Peptides
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