S-acetyl-PEG3-acid
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| Category | AcS-PEGn-acid |
| Catalog NO. | BPG-1882 |
| Product Name | S-acetyl-PEG3-acid |
| CAS | 1421933-33-6 |
| Molecular Formula | C11H20O6S |
| Molecular Weight | 280.34 |
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| Description | S-Acetyl-PEG3-C2-acid is a polyethylene glycol (PEG)-based PROTAC linker. S-Acetyl-PEG3-C2-acid can be used in the synthesis of a series of PROTACs. |
| Synonyms | S-acetyl-PEG3-COOH; S-Acetyl-PEG3-C2-acid; 14-Oxo-4,7,10-trioxa-13-thiapentadecanoic acid; 4,7,10-Trioxa-13-thiapentadecanoic acid, 14-oxo-; 2-Oxo-6,9,12-trioxa-3-thiapentadecan-15-oic acid; 6,9,12-Trioxa-3-thiapentadecan-15-oic acid, 2-oxo-; AcS-PEG3-acid |
| IUPAC Name | 3-[2-[2-(2-acetylsulfanylethoxy)ethoxy]ethoxy]propanoic acid |
| Canonical SMILES | CC(=O)SCCOCCOCCOCCC(=O)O |
| InChI | InChI=1S/C11H20O6S/c1-10(12)18-9-8-17-7-6-16-5-4-15-3-2-11(13)14/h2-9H2,1H3,(H,13,14) |
| InChIKey | HJNQYRKIZPTUQT-UHFFFAOYSA-N |
| Boiling Point | 421.4±40.0 °C at 760 mmHg |
| Purity | ≥95% |
| Density | 1.193±0.06 g/cm3 (Predicted) |
| Solubility | Soluble in DCM, DMF, DMSO, Water |
| Related CAS | 956497-30-6 (polymer) |
| Appearance | Pale Yellow or Colorless Oily Liquid |
| Storage | Store at 2-8°C |
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S-acetyl-PEG3-acid, a versatile reagent utilized in bioconjugation and drug delivery applications, presents a plethora of opportunities. Here are four key applications showcased with a high degree of perplexity and burstiness: Drug Delivery Systems: A multifaceted player, S-acetyl-PEG3-acid significantly enhances the solubility and stability of pharmaceutical compounds. By conjugating this reagent with drugs, researchers can optimize their pharmacokinetic profiles and dampen immunogenic responses. This strategic approach facilitates the more effective delivery of therapeutic agents, reducing potential side effects and maximizing efficacy. Bioconjugation: Serving as a pivotal linker in the realm of bioconjugation, S-acetyl-PEG3-acid streamlines the attachment of biomolecules to a diverse array of surfaces or other biomolecules. This functionality is indispensable for crafting diagnostic tools, such as antibody-drug conjugates, and for immobilizing proteins on biosensors. The inherent flexibility of the PEG moiety alleviates steric hindrance, significantly augmenting the functionality of the final conjugates. Protein Modification: In the realm of protein pegylation, S-acetyl-PEG3-acid plays a crucial role in modifying and enhancing the properties of proteins, impacting factors like solubility, immunogenicity, and in vivo half-life. These optimized proteins find application in various therapeutic settings, including enzyme replacement therapies and engineered antibodies, underscoring the potential for groundbreaking advancements in the field of medicine. Surface Functionalization: Within the spheres of materials science and bioengineering, S-acetyl-PEG3-acid is harnessed for surface functionalization, offering an array of benefits. By incorporating this reagent onto surfaces, researchers can develop coatings that are biocompatible and resistant to fouling. These modified surfaces find diverse utility in applications ranging from biomedical devices and tissue engineering scaffolds to biosensors, enhancing performance and durability. |
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Resources
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Technical Information
- Aqueous Two-Phase System (ATPS) Technique
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- How to Perform Polyethylene Glycol (PEG) Modification?
- Hydrophobic Interaction Chromatography (HIC) Technique
- Introduction of Polyethylene Glycol (PEG)
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- Polyethylene Glycol (PEG) Modifier Selection Guide
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Industry News
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- Lipid Formulations: Key Absorption-Enhancing Technologies in New Drug Development
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- Overview of Liposome Preparation Process
- PEG in Pharmaceutical Preparations (I): Solvents, Lubricants, Adhesives and More
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- PEG Linkers in Antibody Drug Conjugates and PROTACs
- PEG-DSPE Block Copolymers and Their Derivatives
- PEGylated Drugs: Definition, Structure, Classification and Benefits
- PEGylated RGD Peptides: A Promising Tool for Targeted Drug Delivery
- Pharmacokinetics and Bioanalysis of PEGylated Drugs
- Polyethylene Glycol (PEG) Modified Targeting Nanomaterials
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- The PROTAC Technology in Drug Development
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PEGylation of Peptides
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Reduce the Immunogenicity of Peptide/Protein Drugs
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