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Propargyl-PEG4-tos
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| Category | Small-molecule Heterobifunctional PEG |
| Catalog NO. | BPG-2065 |
| Product Name | Propargyl-PEG4-tos |
| CAS | 875770-32-4 |
| Molecular Formula | C18H26O7S |
| Molecular Weight | 386.46 |
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| Description | Propargyl-PEG4-Tos is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-Tos is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
| Synonyms | Propargyl-PEG5-Tos; 3,6,9,12-Tetraoxapentadec-14-yn-1-yl 4-methylbenzenesulfonate |
| IUPAC Name | 2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate |
| Canonical SMILES | CC1=CC=C(C=C1)S(=O)(=O)OCCOCCOCCOCCOCC#C |
| InChI | InChI=1S/C18H26O7S/c1-3-8-21-9-10-22-11-12-23-13-14-24-15-16-25-26(19,20)18-6-4-17(2)5-7-18/h1,4-7H,8-16H2,2H3 |
| InChIKey | VUJIUZITHCTEAF-UHFFFAOYSA-N |
| Boiling Point | 498.1±45.0 °C at 760 mmHg |
| Flash Point | 255.0±28.7 °C |
| Purity | >98.0% |
| Density | 1.2±0.1 g/cm3 |
| Solubility | 10 mm in DMSO |
| Appearance | Solid |
| Shelf Life | 0-4°C for short term (days to weeks), or -20°C for long term (months). |
| Storage | Store at -20 °C, keep in dry and avoid sunlight. |
| Vapor Pressure | 0.0±1.2 mmHg at 25°C |
| LogP | 0.78 |
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Technical Information
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Industry News
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- Liposome in Drug Delivery
- Overview of Liposome Preparation Process
- PEG in Pharmaceutical Preparations (I): Solvents, Lubricants, Adhesives and More
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- PEG Linkers in Antibody Drug Conjugates and PROTACs
- PEG-DSPE Block Copolymers and Their Derivatives
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- PEGylated RGD Peptides: A Promising Tool for Targeted Drug Delivery
- Pharmacokinetics and Bioanalysis of PEGylated Drugs
- Polyethylene Glycol (PEG) Modified Targeting Nanomaterials
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- The PROTAC Technology in Drug Development
- Vaccines: Definition, History, Ingredients, Types and Mechanism of Action
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- What are Lipid Nanoparticles and Their Applications?
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