Propargyl-PEG2-acid
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Category | Small-molecule Heterobifunctional PEG |
Catalog NO. | BPG-1718 |
Product Name | Propargyl-PEG2-acid |
CAS | 1859379-85-3 |
Molecular Formula | C8H12O4 |
Molecular Weight | 172.18 |
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Description | Propargyl-PEG2-acid is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
Synonyms | Propyne-PEG1-CH2CH2COOH; 3-(2-(Prop-2-yn-1-yloxy)ethoxy)propanoic acid; 3-[2-(2-Propyn-1-yloxy)ethoxy]propanoic acid; Propargyl-PEG1-COOH; Propanoic acid, 3-[2-(2-propyn-1-yloxy)ethoxy]- |
IUPAC Name | 3-(2-prop-2-ynoxyethoxy)propanoic acid |
Canonical SMILES | C#CCOCCOCCC(=O)O |
InChI | InChI=1S/C8H12O4/c1-2-4-11-6-7-12-5-3-8(9)10/h1H,3-7H2,(H,9,10) |
InChIKey | NNWHATPXNWOQKD-UHFFFAOYSA-N |
Boiling Point | 306.6±27.0°C at 760 mmHg |
Purity | ≥98.0% |
Density | 1.1±0.1 g/cm3 |
Solubility | Soluble in DMSO |
Appearance | Pale Yellow Oily Matter |
Shelf Life | 0-4°C for short term (days to weeks), or -20°C for long term (months). |
Storage | Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years) |
Pictogram(s) | Corrosive, Irritant |
Signal | Danger |
Precautionary Statement Codes | P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 |
Propargyl-PEG2-acid, a versatile compound widely utilized in bioconjugation and chemical biology, finds diverse applications in scientific research. Here are four key applications presented with high perplexity and burstiness: Protein Labeling: A cornerstone in protein research, Propargyl-PEG2-acid plays a pivotal role in protein labeling through the intricate chemistry of click reactions. This compound engages in reactions with azide-functionalized molecules, forming robust triazole linkages that facilitate the attachment of various probes or tags to proteins. This method proves invaluable for exploring protein function and interactions both in controlled laboratory environments and dynamic living systems. Drug Delivery: In the realm of pharmaceutical innovation, Propargyl-PEG2-acid emerges as a key player in the realm of drug delivery systems. By manipulating drug molecules or carrier systems through the addition of PEG chains, the compound enhances solubility, stability, and bioavailability of therapeutic agents. This modification aids in achieving targeted and controlled release of drugs, ultimately enhancing therapeutic efficacy and patient outcomes through a sophisticated interplay of chemistry and biology. Surface Modification: Delving into the intricacies of surface chemistry, Propargyl-PEG2-acid finds its niche in functionalizing surfaces within biomedical devices and biosensors. By coating surfaces with PEG, the compound mitigates nonspecific protein adsorption and elevates biocompatibility, a critical aspect in the development of cutting-edge medical implants, diagnostic tools, and research instruments that engage seamlessly with biological systems. This sophisticated surface modification technique underscores the intersection of materials science and biological engineering, with far-reaching implications in advancing healthcare technologies. Bioconjugation Chemistry: Anchored in the realm of bioconjugation, Propargyl-PEG2-acid stands as a foundational building block for crafting intricate biomolecular assemblies. This compound serves as a versatile linker, connecting with other reactive groups such as amines or thiols to enable the construction of complex bioconjugates. The flexibility of Propargyl-PEG2-acid as a key reagent in the design of multifunctional biomaterials and nanomedicines underscores its significance in shaping the landscape of modern biochemistry and nanotechnology. |
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Resources
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Technical Information
- Aqueous Two-Phase System (ATPS) Technique
- Capillary Electrophoresis (CE) Technique
- Enzyme-linked immunosorbent assay (ELISA) Technique
- High performance liquid chromatography (HPLC) Technique
- How to Perform Polyethylene Glycol (PEG) Modification?
- Hydrophobic Interaction Chromatography (HIC) Technique
- Introduction of Polyethylene Glycol (PEG)
- Ion Exchange Chromatography (IEX) Technique
- PEG for Chemical Synthesis
- PEG for Cosmetic Application
- PEG for Drug Delivery
- PEG for Imaging Diagnosis
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- PEG Purification Techniques of Plasmid DNA
- PEGylated Protein Purification Techniques
- Polyethylene Glycol (PEG) Modifier Selection Guide
- Radiolabeling Technique
- SDS-PAGE Technique
- Size Exclusion Chromatography (SEC) Technique
- Ultrafiltration Technique
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Industry News
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- PEG Linkers in Antibody Drug Conjugates and PROTACs
- PEG-DSPE Block Copolymers and Their Derivatives
- PEGylated Drugs: Definition, Structure, Classification and Benefits
- PEGylated RGD Peptides: A Promising Tool for Targeted Drug Delivery
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- Polyethylene Glycol (PEG) Modified Targeting Nanomaterials
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- The PROTAC Technology in Drug Development
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- What are Lipids?
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PEGylation of Peptides
and Proteins
Reduce the Immunogenicity of Peptide/Protein Drugs
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PEG linkers For Drug
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