(mPEG)2-lys-MAL, MW 40k

(mPEG)2-lys-MA,L MW 40k is a polyethylene glycol derivative often used in the bioconjugation and drug delivery fields. Here are some key applications of (mPEG)2-lys-MAL, MW 40k:

Drug Delivery: (mPEG)2-lys-MAL is utilized in the formulation of drug delivery systems to enhance the solubility and stability of therapeutic agents. By attaching polyethylene glycol (PEG) to drugs, their circulation time in the bloodstream is prolonged, improving efficacy. This conjugation also helps in reducing the immunogenicity and toxicity of the administered drugs.

Protein Conjugation: This PEG derivative is employed to modify proteins and peptides, enhancing their pharmacokinetic properties. By conjugating (mPEG)2-lys-MAL to biomolecules, researchers can increase their solubility, reduce their degradation, and prolong their half-life. These modifications are crucial for developing more effective therapeutic proteins and enzymes.

Biosensor Development: (mPEG)2-lys-MAL is used in biosensor technologies to immobilize biomolecules onto surfaces without compromising their activity. The maleimide group in the molecule allows for site-specific conjugation to thiol-containing proteins. This ensures a stable and oriented attachment, improving sensor performance and reliability.

Surface Modification: In biomaterials science, (mPEG)2-lys-MAL is applied for surface modification of medical devices and implants. Coating surfaces with PEG can reduce protein adsorption and cell adhesion, minimizing the risk of thrombosis and immune response. This leads to improved biocompatibility and longevity of medical implants.