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Methyltetrazine-amino-PEG8-amine

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Category	Small-molecule Heterobifunctional PEG
Catalog NO.	BPG-2419
Product Name	Methyltetrazine-amino-PEG8-amine
Molecular Formula	C29H48N6O9
Molecular Weight	624.73

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Description	Methyltetrazine-amino-PEG8-amine is a heterobifunctional PEG linker containing a methyltetrazine group and an amino group. The methyltetrazine group is reactive with carboxylic acids and activated esters via click chemistry, and the amino group can react with carboxylic acids, activated NHS esters, carbonyls and so on.
Synonyms	Methyltetrazine-amino-PEG8-amine; SCHEMBL26154046; Methyltetrazine-CH2NHCO-PEG8-CH2CH2NH2; 1-Amino-N-(4-(6-methyl-1,2,4,5-tetrazin-3-yl)benzyl)-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-amide; 2143958-58-9
IUPAC Name	3-[2-[2-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-N-[[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methyl]propanamide
Canonical SMILES	CC1=NN=C(N=N1)C2=CC=C(C=C2)CNC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCN
InChI	InChI=1S/C29H48N6O9/c1-25-32-34-29(35-33-25)27-4-2-26(3-5-27)24-31-28(36)6-8-37-10-12-39-14-16-41-18-20-43-22-23-44-21-19-42-17-15-40-13-11-38-9-7-30/h2-5H,6-24,30H2,1H3,(H,31,36)
InChIKey	DPSOZFFDQJUYFH-UHFFFAOYSA-N
Purity	>97%
Storage	Store at -18°C

Methyltetrazine-amino-PEG8-amine, a versatile chemical linker in bioconjugation chemistry and drug delivery systems, finds diverse applications. Here are four key applications presented with high perplexity and burstiness:

Drug Conjugation: Utilizing Methyltetrazine-amino-PEG8-amine for site-specific drug conjugation boosts the therapeutic properties of drugs by enhancing their reactivity with trans-cyclooctene (TCO) derivatives. This innovative approach enables the creation of targeted drug-delivery systems, leading to enhanced drug stability, bioavailability, and reduced off-target effects, revolutionizing drug delivery methods.

Bioimaging: In the dynamic field of bioimaging, Methyltetrazine-amino-PEG8-amine plays a crucial role in conjugating imaging agents to biological molecules, facilitating the visualization of intricate cellular processes. Its compatibility with click-chemistry guarantees rapid and stable attachment to specific targets, enabling precise imaging of cellular and molecular events. This application is indispensable for advancing diagnostics and conducting cutting-edge research in cellular biology.

Protein Labeling: Serving as a potent reagent for protein functionalization, this compound enables the attachment of various tags or probes to proteins, including fluorescent dyes, biotin, or other molecular markers. By linking these molecules to proteins, researchers can explore protein interactions, localization, and functions in diverse biological contexts, offering invaluable insights in proteomics and cell biology research.

Surface Functionalization: Methyltetrazine-amino-PEG8-amine also plays a pivotal role in surface functionalization, empowering the attachment of specific biomolecules to surfaces like nanoparticles and microarrays. This application is essential for developing innovative biosensors, diagnostic devices, and therapeutic delivery systems. Functionalized surfaces exhibit heightened specificity and sensitivity towards their targets, enhancing the performance of biosensing and diagnostic platforms, pushing the boundaries of bioengineering.

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