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Mal-PEG5-acid

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Category Mal-PEGn-acid
Catalog NO. BPG-0346
Product Name Mal-PEG5-acid
CAS 1286755-26-7
Molecular Formula C17H27NO9
Molecular Weight 389.40
Mal-PEG5-acid
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Product Information

Description Mal-PEG5-acid is a non-cleavable 5-unit PEG ADC linker that is used in the synthesis of antibody conjugated drugs (ADCs). It is also a PROTAC linker, belonging to the PEG class, which can be used to synthesize PROTAC molecules.
Synonyms Mal-PEG5-CH2CH2COOH; Maleimide-PEG5-CH2CH2COOH; Mal-PEG5-COOH; Mal-PEG5-propionic acid; 1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3,6,9,12,15-pentaoxaoctadecan-18-oic acid; 4,7,10,13,16-Pentaoxaoctadecanoic acid, 18-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-
IUPAC Name 3-[2-[2-[2-[2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
Canonical SMILES C1=CC(=O)N(C1=O)CCOCCOCCOCCOCCOCCC(=O)O
InChI InChI=1S/C17H27NO9/c19-15-1-2-16(20)18(15)4-6-24-8-10-26-12-14-27-13-11-25-9-7-23-5-3-17(21)22/h1-2H,3-14H2,(H,21,22)
InChIKey HFYDLVZXYONWDG-UHFFFAOYSA-N
Boiling Point 549.3±50.0°C at 760 mmHg
Purity ≥95%
Density 1.2±0.1 g/cm3
Solubility Soluble in DCM, DMSO
Related CAS 357277-61-3 (polymer) 2422928-26-3 (polymer)
Appearance Light Yellow or White Solid
Storage Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)

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PEGylation of Peptides and Proteins

PEGylation of Peptides
and Proteins

Reduce the Immunogenicity of Peptide/Protein Drugs

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