Mal-PEG5-acid
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| Category | Mal-PEGn-acid |
| Catalog NO. | BPG-0346 |
| Product Name | Mal-PEG5-acid |
| CAS | 1286755-26-7 |
| Molecular Formula | C17H27NO9 |
| Molecular Weight | 389.40 |
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| Description | Mal-PEG5-acid is a non-cleavable 5-unit PEG ADC linker that is used in the synthesis of antibody conjugated drugs (ADCs). It is also a PROTAC linker, belonging to the PEG class, which can be used to synthesize PROTAC molecules. |
| Synonyms | Mal-PEG5-CH2CH2COOH; Maleimide-PEG5-CH2CH2COOH; Mal-PEG5-COOH; Mal-PEG5-propionic acid; 1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3,6,9,12,15-pentaoxaoctadecan-18-oic acid; 4,7,10,13,16-Pentaoxaoctadecanoic acid, 18-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)- |
| IUPAC Name | 3-[2-[2-[2-[2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid |
| Canonical SMILES | C1=CC(=O)N(C1=O)CCOCCOCCOCCOCCOCCC(=O)O |
| InChI | InChI=1S/C17H27NO9/c19-15-1-2-16(20)18(15)4-6-24-8-10-26-12-14-27-13-11-25-9-7-23-5-3-17(21)22/h1-2H,3-14H2,(H,21,22) |
| InChIKey | HFYDLVZXYONWDG-UHFFFAOYSA-N |
| Boiling Point | 549.3±50.0°C at 760 mmHg |
| Purity | ≥95% |
| Density | 1.2±0.1 g/cm3 |
| Solubility | Soluble in DCM, DMSO |
| Appearance | Light Yellow or White Solid |
| Storage | Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years) |
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Technical Information
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Industry News
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- Applications of Polyethylene Glycol (PEG) as Medical Devices
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- PEG in Pharmaceutical Preparations (I): Solvents, Lubricants, Adhesives and More
- PEG in Pharmaceutical Preparations (II): Stabilizers, Plasticizers and Modification Materials
- PEG Linkers in Antibody Drug Conjugates and PROTACs
- PEG-DSPE Block Copolymers and Their Derivatives
- PEGylated RGD Peptides: A Promising Tool for Targeted Drug Delivery
- Polyethylene Glycol (PEG) Modified Targeting Nanomaterials
- Preparation Method of PEG Hydrogel
- The PROTAC Technology in Drug Development
- What are Biotinylation and Biotinylated PEG?
- What are Lipid Excipients and Their Applications?
- What are Lipid Nanoparticles and Their Applications?
- What are Lipid-Drug Conjugates (LDCs)?
- What are Lipids?
- What are Monodispersed and Polydispersed PEGs?
- What are PEG Lipids?
- What are Phospholipids?
- What is Click Chemistry?
- What is Hydrogel?
- What is Methoxy Polyethylene Glycol (mPEG)?
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- What is the Formulation of Lipid Nanoparticles (LNPs)?
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PEGylation of Peptides
and Proteins
Reduce the Immunogenicity of Peptide/Protein Drugs
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