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Hydroxy-PEG4-propionic acid

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Category	Small-molecule Heterobifunctional PEG
Catalog NO.	BPG-1857
Product Name	Hydroxy-PEG4-propionic acid
CAS	937188-59-5
Molecular Formula	C11H22O7
Molecular Weight	266.29

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Description	Hydroxy-PEG4-acid is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Synonyms	OH-PEG4-COOH; HO-PEG4-Propionic acid; HO-PEG4-CH2CH2COOH; Hydroxy-PEG4-acid; 1-Hydroxy-3,6,9,12-tetraoxapentadecan-15-oic acid; 15-Hydroxy-4,7,10,13-tetraoxapentadecanoic Acid; α,ω-hydroxy-propionic acid tetraethylene glycol; 4,7,10,13-Tetraoxapentadecanoic acid, 15-hydroxy-; 3,6,9,12-Tetraoxapentadecan-15-oic acid, 1-hydroxy-
IUPAC Name	3-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]propanoic acid
Canonical SMILES	C(COCCOCCOCCOCCO)C(=O)O
InChI	InChI=1S/C11H22O7/c12-2-4-16-6-8-18-10-9-17-7-5-15-3-1-11(13)14/h12H,1-10H2,(H,13,14)
InChIKey	UQWLGZFJGVEDCQ-UHFFFAOYSA-N
Boiling Point	420.7±40.0 °C at 760 mmHg
Flash Point	155.5±20.8 °C
Purity	>98.0%
Density	1.169±0.06 g/cm3 (Predicted)
Solubility	Soluble in DMSO
Appearance	Pale Yellow or Colorless Oily Matter
Shelf Life	-20°C 3 years powder; -80°C 2 years in solvent
Storage	Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)
Vapor Pressure	0.0±2.2 mmHg at 25°C
LogP	-2.07

Hydroxy-PEG4-propionic acid, a versatile chemical compound widely employed in biochemical and pharmaceutical realms, boasts diverse applications. Here are four key applications presented with heightened perplexity and burstiness:

Drug Conjugation: A cornerstone in drug conjugation, Hydroxy-PEG4-propionic acid plays a pivotal role in enhancing the pharmacokinetics and bioavailability of therapeutic agents. By tethering the polyethylene glycol (PEG) chain to drugs, it enhances solubility and stability, thereby augmenting drug delivery efficiency and diminishing immunogenicity. This modification not only boosts treatment effectiveness but also ensures a safer therapeutic experience.

Bioconjugation: Across the realm of bioconjugation, this compound finds widespread utility in linking biomolecules like proteins, antibodies, and peptides to diverse surfaces or molecular entities. The PEG chain acts as a strategic spacer, reducing steric hindrance and preserving biomolecule functionality. Applications span diagnostic assays, biosensors, and targeted drug delivery systems, showcasing the versatility of this compound in bridging molecular domains.

Surface Functionalization: Delving into surface modification, Hydroxy-PEG4-propionic acid is harnessed to engineer hydrophilic, non-fouling surfaces on an array of biomedical materials such as medical devices and nanoparticles. The PEG layer's prowess in minimizing protein adsorption and cellular adhesion is pivotal in thwarting undesirable biological interactions. This technology finds particular resonance in the design of implantable devices and drug transport systems, heralding a new era of bio-compatible material engineering.

Targeted Therapy: In the realm of targeted therapy, Hydroxy-PEG4-propionic acid emerges as a game-changer, facilitating the precise modification of therapeutic agents for enhanced targeting specificity. By conjugating it with ligands or antibodies, this compound navigates drugs with precision to disease sites like tumor cells while sparing healthy tissues. This precision-guided strategy aims to amplify therapeutic efficacy while curbing adverse side effects.

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