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HO-PEG8-OH

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Category	Small-molecule Polyethylene Glycol
Catalog NO.	BPG-2041
Product Name	HO-PEG8-OH
CAS	5117-19-1
Molecular Formula	C16H34O9
Molecular Weight	370.44

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Description	Octaethylene Glycol (CAS# 5117-19-1) is part of a leaf extract (Murdannia Bracteata) which was shown to exhibit antioxidant, antimicrobial and anti-cancer properties.Octaethylene Glycol also shows potential application as functional hydraulic fluids.
Synonyms	Octaethylene Glycol; 3,6,9,12,15,18,21-Heptaoxatricosane-1,23-diol; Octanethyl glycol; HO-dPEG8-OH; 2-(2-{2-[2-(2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethan-1-ol; NSC 97395
IUPAC Name	2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
Canonical SMILES	C(COCCOCCOCCOCCOCCOCCOCCO)O
InChI	InChI=1S/C16H34O9/c17-1-3-19-5-7-21-9-11-23-13-15-25-16-14-24-12-10-22-8-6-20-4-2-18/h17-18H,1-16H2
InChIKey	GLZWNFNQMJAZGY-UHFFFAOYSA-N
Boiling Point	175°C at 0.01 Torr
Melting Point	22°C
Purity	≥95%
Density	1.13±0.06 g/cm3 (Predicted)
Solubility	Soluble in DMSO (10 mm)
Appearance	Pale Yellow or Colorless Liquid
Application	Octaethylene Glycol is part of a leaf extract (Murdannia Bracteata) which was shown to exhibit antioxidant, antimicrobial and anti-cancer properties.Octaethylene Glycol also shows potential application as functional hydraulic fluids.
Storage	Store at 2-8°C
Exact Mass	370.22028266
LogP	-0.91280

HO-PEG8-OH, also known as Hydroxy-Polyethylene Glycol 8-OH, is a versatile chemical compound with a variety of applications in biosciences. Here are some key applications of HO-PEG8-OH:

Drug Delivery Systems: HO-PEG8-OH is utilized in the formulation of drug delivery systems, where it acts as a linker or stabilizer. Its hydrophilic properties enhance the solubility and stability of hydrophobic drugs, facilitating their delivery to targeted sites within the body. This results in improved therapeutic efficacy and reduced side effects.

Bioconjugation: In bioconjugation, HO-PEG8-OH is employed to modify proteins, peptides, and other biomolecules. By attaching PEG chains to these molecules, researchers can enhance their solubility, reduce immunogenicity, and prolong their circulation time in the bloodstream. This modification is especially valuable in developing long-acting biopharmaceuticals and diagnostics.

Tissue Engineering: HO-PEG8-OH is used in the preparation of hydrogels for tissue engineering applications. These hydrogels provide a biocompatible and tunable matrix for cell encapsulation and tissue growth. As a result, HO-PEG8-OH-based hydrogels are instrumental in creating scaffolds for regenerative medicine and 3D cell culture systems.

Surface Modification: HO-PEG8-OH is employed to modify the surfaces of medical devices and biomaterials. By coating surfaces with PEG, it helps in reducing protein adsorption and minimizing cellular adhesion, thereby preventing biofouling and improving biocompatibility. This application is crucial for enhancing the performance and longevity of implants and other medical devices.

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