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DSPE-RGD Sodium salt

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Category Standards
Catalog NO. BPG-3138
Product Name DSPE-RGD Sodium salt
CAS 2260795-79-5
Molecular Formula C68H120N9Na2O18PS
Molecular Weight 1460.75
DSPE-RGD Sodium salt
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Product Information

Description RGD modified liposomes show potential for cancer research.
Synonyms 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[4-(p-(cysarginylglycylaspartate-maleimidomethyl)cyclohexane-carboxamide] (sodium salt)
IUPAC Name disodium;(3S)-3-[[2-[[(2S)-2-azaniumyl-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-4-[[(1R)-1-carboxylato-2-[1-[[4-[2-[[(2R)-2,3-di(octadecanoyloxy)propoxy]-oxidophosphoryl]oxyethylcarbamoyl]cyclohexyl]methyl]-2,5-dioxopyrrolidin-3-yl]sulfanylethyl]amino]-4-oxobutanoate
Canonical SMILES CCCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)([O-])OCCNC(=O)C1CCC(CC1)CN2C(=O)CC(C2=O)SCC(C(=O)[O-])NC(=O)C(CC(=O)[O-])NC(=O)CNC(=O)C(CCCN=C(N)N)[NH3+])OC(=O)CCCCCCCCCCCCCCCCC.[Na+].[Na+]
InChI InChI=1S/C68H122N9O18PS.2Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-35-61(82)92-48-53(95-62(83)36-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2)49-94-96(90,91)93-43-42-72-63(84)52-39-37-51(38-40-52)47-77-59(79)45-57(66(77)87)97-50-56(67(88)89)76-65(86)55(44-60(80)81)75-58(78)46-74-64(85)54(69)34-33-41-73-68(70)71;;/h51-57H,3-50,69H2,1-2H3,(H,72,84)(H,74,85)(H,75,78)(H,76,86)(H,80,81)(H,88,89)(H,90,91)(H4,70,71,73);;/q;2*+1/p-2/t51?,52?,53-,54+,55+,56+,57?;;/m1../s1
InChIKey BNMYYFNFRONMOH-CIJOWSANSA-L
Purity >99%
Appearance White Powder
Shelf Life 1 Year
Storage Store at -20°C
Exact Mass 1459.801
Hygroscopic No
Light Sensitive No
Percent Composition C 55.91%, H 8.28%, N 8.63%, Na 3.15%, O 19.72%, P 2.12%, S 2.20%
References 1. Chen CW, Lu DW, Yeh MK, Shiau CY, Chiang CH. Novel RGD-lipid conjugate-modified liposomes for enhancing siRNA delivery in human retinal pigment epithelial cells. Int J Nanomedicine. 2011;6:2567-80. doi: 10.2147/IJN.S24447. Epub 2011 Oct 26. PMID: 22128247; PMCID: PMC3225218. PubMed ID: 22128247.
2. Cao Y, Zhou Y, Zhuang Q, Cui L, Xu X, Xu R, He X. Anti-tumor effect of RGD modified PTX loaded liposome on prostatic cancer. Int J Clin Exp Med. 2015 Aug 15;8(8):12182-91. PMID: 26550128; PMCID: PMC4612813. PubMed ID: 26550128.

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