DSPE-PEG-COOH sodium salt

* Please be kindly noted products are not for therapeutic use. We do not sell to patients.

Category	Functionalized PEG Lipids
Catalog NO.	BPG-2972
Product Name	DSPE-PEG-COOH sodium salt
CAS	1403744-37-5
Molecular Formula	(C2H4O)nC45H86NO12P.Na
Molecular Weight	2780.38

Scheme Design
Custom Synthesis
cGMP Manufacturing
Quality Assurance

Product Information
References
Documents
Reviews

Product Information

Description	DSPE-PEG-COOH is DSPE-PEG with a carboxylic acid. It can be used for PEG-biochemical conjugation, and be utilized in micelles, liposomes, and other lipid-based drug carriers.
Synonyms	Poly(oxy-1,2-ethanediyl), α-(carboxymethyl)-ω-[[(10R)-7-hydroxy-7-oxido-2,13-dioxo-10-[(1-oxooctadecyl)oxy]-6,8,12-trioxa-3-aza-7-phosphatriacont-1-yl]oxy]-, sodium salt (1:1)
Purity	95%
Solubility	Soluble in warm aqeous solution as well as most organic solvents.
Appearance	Powder
Shelf Life	1 Year.
Storage	Store at -20°C
Exact Mass	2778.7
Hygroscopic	Yes
Light Sensitive	No
Percent Composition	C 56.59%, H 9.32%, N 0.50%, Na 0.83%, O 31.65%, P 1.11%

References

1. Mashreghi M, Zamani P, Moosavian SA, Jaafari MR. Anti-Epcam Aptamer (Syl3c)-Functionalized Liposome for Targeted Delivery Of Doxorubicin: In Vitro And In Vivo Antitumor Studies in Mice Bearing C26 Colon Carcinoma. Nanoscale Res Lett. 2020 May 7;15(1):101. doi: 10.1186/s11671-020-03334-9. PMID: 32383027; PMCID: PMC7206479. PubMed ID: 32383027.
2. Kong L, Li XT, Ni YN, Xiao HH, Yao YJ, Wang YY, Ju RJ, Li HY, Liu JJ, Fu M, Wu YT, Yang JX, Cheng L. Transferrin-Modified Osthole PEGylated Liposomes Travel the Blood-Brain Barrier and Mitigate Alzheimer's Disease-Related Pathology in APP/PS-1 Mice. Int J Nanomedicine. 2020 Apr 23;15:2841-2858. doi: 10.2147/IJN.S239608. PMID: 32425521; PMCID: PMC7186891. PubMed ID: 32425521.
3. An J, Forchheimer D, Sävmarker J, Brülls M, Frenning G. Nanoscale characterization of PEGylated phospholipid coatings formed by spray drying on silica microparticles. J Colloid Interface Sci. 2020 May 21;577:92-100. doi: 10.1016/j.jcis.2020.05.045. Epub ahead of print. PMID: 32473480. PubMed ID: 32473480.
4. Kuo YC, Lou YI, Rajesh R. Dual functional liposomes carrying antioxidants against tau hyperphosphorylation and apoptosis of neurons. J Drug Target. 2020 May 12:1-12. doi: 10.1080/1061186X.2020.1761819. Epub ahead of print. PMID: 32338078. PubMed ID: 32338078.
5. Benne N, Martins Cardoso R, Boyle AL, Kros A, Jiskoot W, Kuiper J, Bouwstra J, Van Eck M, Slütter B. Complement Receptor Targeted Liposomes Encapsulating the Liver X Receptor Agonist GW3965 Accumulate in and Stabilize Atherosclerotic Plaques. Adv Healthc Mater. 2020 May;9(10):e2000043. doi: 10.1002/adhm.202000043. Epub 2020 Apr 24. PMID: 32329226. PubMed ID: 32329226.
6. Wei Y, Liu S, Pan C, Yang Z, Liu Y, Yong J, Quan L. Molecular Antenna-Sensitized Upconversion Nanoparticle for Temperature Monitored Precision Photothermal Therapy. Int J Nanomedicine. 2020 Mar 2;15:1409-1420. doi: 10.2147/IJN.S236371. PMID: 32184595; PMCID: PMC7060035. PubMed ID: 32184595.
7. Lee SWL, Campisi M, Osaki T, Possenti L, Mattu C, Adriani G, Kamm RD, Chiono V. Modeling Nanocarrier Transport across a 3D In Vitro Human Blood-Brain-Barrier Microvasculature. Adv Healthc Mater. 2020 Apr;9(7):e1901486. doi: 10.1002/adhm.201901486. Epub 2020 Mar 3. PMID: 32125776. PubMed ID: 32125776.
8. Ye S , Liu Y , Lu Y , Ji Y , Mei L , Yang M , Gong X , Gu Q , Li D , Yang F , Li CJ . Cyclic RGD functionalized liposomes targeted to activated platelets for thrombosis dual-mode magnetic resonance imaging. J Mater Chem B. 2020 Jan 22;8(3):447-453. doi: 10.1039/c9tb01834d. PMID: 31833530. PubMed ID: 31833530.
9. Ramesh A , Kumar S , Nguyen A , Brouillard A , Kulkarni A . Lipid-based phagocytosis nanoenhancer for macrophage immunotherapy. Nanoscale. 2020 Jan 23;12(3):1875-1885. doi: 10.1039/c9nr08670f. PMID: 31903467. PubMed ID: 31903467.
10. Yang F, Medik Y, Li L, Tian X, Fu D, Brouwer KLR, Wagner K, Sun B, Sendi H, Mi Y, Wang AZ. Nanoparticle Drug Delivery Can Reduce the Hepatotoxicity of Therapeutic Cargo. Small. 2020 Jan 23:e1906360. doi: 10.1002/smll.201906360. Epub ahead of print. PMID: 31972070. PubMed ID: 31972070.

Reviews

If you have any suggestions or comments about mPEG-Br, please submit a review immediately.