DNP-PEG6-DNP

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Category	DNP-PEGn-DNP
Catalog NO.	BPG-1616
Product Name	DNP-PEG6-DNP
Molecular Formula	C26H36N6O14
Molecular Weight	656.60

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Description	DNP-PEG6-DNP is a PEG linker containing two DNP moieties. DNP is involved in biological applications such as participating in ion transport across membranes. The hydrophilic PEG chain increases the solubility of the compound in aqueous media.
Synonyms	N1,N20-bis(2,4-dinitrophenyl)-3,6,9,12,15,18-hexaoxaicosane-1,20-diamine
IUPAC Name	N-[2-[2-[2-[2-[2-[2-[2-(2,4-dinitroanilino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]-2,4-dinitroaniline
Canonical SMILES	O=[N+](C1=CC=C(C([N+]([O-])=O)=C1)NCCOCCOCCOCCOCCOCCOCCNC2=CC=C([N+]([O-])=O)C=C2[N+]([O-])=O)[O-]
InChI	InChI=1S/C26H36N6O14/c33-29(34)21-1-3-23(25(19-21)31(37)38)27-5-7-41-9-11-43-13-15-45-17-18-46-16-14-44-12-10-42-8-6-28-24-4-2-22(30(35)36)20-26(24)32(39)40/h1-4,19-20,27-28H,5-18H2
InChIKey	ZBLZFVHZLXQUCT-UHFFFAOYSA-N
Purity	≥95%
Appearance	Pale Yellow or Colorless Oily Matter
Storage	Store at 2-8°C

DNP-PEG6-DNP is a bifunctional compound widely used in biochemical and biomedical research. Here are some key applications of DNP-PEG6-DNP:

Protein Crosslinking: DNP-PEG6-DNP is used as a crosslinking agent to stabilize protein structures and investigate protein-protein interactions. By linking proteins through its bifunctional ends, researchers can preserve their complex formations for detailed structural analysis. This is particularly useful in studying the architecture and function of large protein complexes.

Drug Delivery Systems: DNP-PEG6-DNP can be utilized to enhance drug delivery systems by attaching therapeutic agents to its PEGylated linker. The PEG6 linker improves solubility and biocompatibility, allowing for more efficient targeting and release of the drug in the body. This enhances the efficacy and reduces the side effects of drug formulations.

Bioconjugation: In bioconjugation applications, DNP-PEG6-DNP facilitates the attachment of biomolecules such as antibodies and peptides to various surfaces. This is essential for the development of biosensors, diagnostic tools, and targeted therapies. The PEG6 spacer provides flexibility, reducing steric hindrance and maintaining the biological activity of the conjugated molecules.

Immunogenicity Studies: Researchers use DNP-PEG6-DNP to study immunogenic responses by conjugating DNP to antigens or other immunogens. This helps in understanding the modulation of immune responses and the development of vaccines. By analyzing the immune reaction to these conjugates, scientists can design more effective immunotherapeutic strategies.

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