DNP-PEG4-DNP

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Category	DNP-PEGn-DNP
Catalog NO.	BPG-1615
Product Name	DNP-PEG4-DNP
CAS	1393130-16-9
Molecular Formula	C22H28N6O12
Molecular Weight	568.50

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Description	DNP-PEG4-DNP is a PEG linker containing two DNP moieties. DNP is involved in biological applications such as participating in ion transport across membranes. The hydrophilic PEG chain increases the solubility of the compound in aqueous media.
Synonyms	N1,N14-bis(2,4-dinitrophenyl)-3,6,9,12-tetraoxatetradecane-1,14-diamine
IUPAC Name	N-[2-[2-[2-[2-[2-(2,4-dinitroanilino)ethoxy]ethoxy]ethoxy]ethoxy]ethyl]-2,4-dinitroaniline
Canonical SMILES	O=[N+](C1=CC=C(C([N+]([O-])=O)=C1)NCCOCCOCCOCCOCCNC2=CC=C([N+]([O-])=O)C=C2[N+]([O-])=O)[O-]
InChI	InChI=1S/C22H28N6O12/c29-25(30)17-1-3-19(21(15-17)27(33)34)23-5-7-37-9-11-39-13-14-40-12-10-38-8-6-24-20-4-2-18(26(31)32)16-22(20)28(35)36/h1-4,15-16,23-24H,5-14H2
InChIKey	ZGBNEUQNYGZQOE-UHFFFAOYSA-N
Purity	≥95%
Appearance	Pale Yellow or Colorless Oily Matter
Storage	Store at 2-8°C

DNP-PEG4-DNP, a bifunctional polyethylene glycol (PEG) linker, plays a pivotal role in biomolecular conjugation across diverse applications. Here are four key applications of DNP-PEG4-DNP portrayed with elevated perplexity and burstiness:

Bioconjugation: Widely embraced in research and diagnostics, DNP-PEG4-DNP serves as a vital linker for binding antibodies, enzymes, or proteins to surfaces or other molecules. The PEG spacer introduces a level of flexibility, mitigating steric hindrance and enhancing the functionality and stability of the conjugated biomolecules. This functionality proves especially valuable in crafting diagnostic assays and therapeutic agents, underscoring its versatile utility in advancing medical science.

Targeted Drug Delivery: The strategic deployment of DNP-PEG4-DNP facilitates the development of precision drug delivery systems tailored to specific cellular or tissue targets. By affixing targeting ligands or antibodies to the DNP moiety, drug-loaded systems can be steered towards designated locations in the body. This targeted approach not only amplifies therapeutic efficacy but also minimizes off-target effects and systemic toxicity.

Immunoassays: Within the realm of immunoassay development, DNP-PEG4-DNP assumes a critical role as a linker for anchoring antigens or antibodies onto assay platforms. This integration elevates the sensitivity and specificity of assays utilized for detecting an array of analytes, ranging from hormones to pathogens and biomarkers.

Protein Modification: In the pursuit of protein enhancement, DNP-PEG4-DNP emerges as a linchpin for advancing solubility, stability, and biocompatibility. Through PEGylation facilitated by DNP-PEG4-DNP, the half-life of therapeutic proteins in circulation can be extended, immunogenicity reduced, and pharmacokinetics optimized. This transformative modification not only paves the way for more efficacious biopharmaceuticals but also prioritizes patient comfort and compliance, underscoring its pivotal role in reshaping the landscape of therapeutic protein engineering.

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