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DNP-PEG11-COOH

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Category	DNP-PEGn-COOH
Catalog NO.	BPG-0193
Product Name	DNP-PEG11-COOH
Molecular Formula	C31H53N3O17
Molecular Weight	739.77

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Description	DNP-PEG11-COOH is a PEG linker containing a DNP and a carboxylic acid moiety. DNP is involved in biological applications such as participating in ion transport across membranes. The terminal carboxylic acid can react with primary amines in the presence of EDC and HATU to form stable amide bonds. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.
Synonyms	DNP-NH-PEG11-C2-acid; DNP-PEG11-acid; 1-((2,4-dinitrophenyl)amino)-3,6,9,12,15,18,21,24,27,30,33-undecaoxahexatriacontan-36-oic acid
IUPAC Name	3-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2,4-dinitroanilino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
Canonical SMILES	O=C(O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O
InChI	InChI=1S/C31H53N3O17/c35-31(36)3-5-41-7-9-43-11-13-45-15-17-47-19-21-49-23-25-51-26-24-50-22-20-48-18-16-46-14-12-44-10-8-42-6-4-32-29-2-1-28(33(37)38)27-30(29)34(39)40/h1-2,27,32H,3-26H2,(H,35,36)
InChIKey	REMFJUWXZUXGSN-UHFFFAOYSA-N
Purity	≥95%
Related CAS	1334178-00-5 (polymer)
Appearance	Pale Yellow or Colorless Oily Matter
Storage	Store at 2-8°C

DNP-PEG11-COOH, a versatile reagent utilized in bioconjugation and polymer science, boasts a multitude of applications. Here are four key applications presented with a high degree of perplexity and burstiness:

Drug Delivery Systems: At the forefront of medical innovation, DNP-PEG11-COOH plays a pivotal role in shaping targeted drug delivery systems. Through its conjugation with therapeutic agents and antibodies, this compound showcases its prowess. The polyethylene glycol (PEG) component not only enhances solubility and stability but also diminishes immunogenicity. Meanwhile, the DNP moiety serves as a platform for further chemical modifications, offering precise control over drug release profiles.

Diagnostic Imaging: In the realm of diagnostic imaging, DNP-PEG11-COOH emerges as a game-changer. By conjugating with imaging agents like fluorophores or radioactive isotopes, it elevates their pharmacokinetics and targeting specificity. The PEGylated structure ensures prolonged circulation time in the bloodstream, facilitating enhanced imaging of diseased tissues. This strategic conjugation fuels the development of cutting-edge imaging techniques for early disease detection and monitoring.

Biomaterial Surface Modification: Delving into biomaterial surface modification, DNP-PEG11-COOH emerges as a transformative tool. Its role in enhancing biocompatibility and reducing nonspecific protein adsorption is paramount. Through the grafting of DNP-PEG11-COOH onto surface coatings, researchers can fashion materials that resist biofouling. Particularly essential in the realm of medical devices, this approach aids in minimizing immune responses and extending device longevity.

Protein Purification: Stepping into the realm of protein purification, DNP-PEG11-COOH shines as a crucial linker in affinity chromatography. Its ability to be conjugated to ligands that selectively bind to target proteins revolutionizes the separation and purification process. This method not only boosts the yield and purity of proteins but also streamlines downstream applications in both research and therapeutic development, propelling the field forward with its efficiency and precision.

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